The Potential Ameliorative Effects of Annona muricata (Linn) on Sodium Fluoride-Induced Toxicity on Haematological Indices and Fecundity of Adult Male Wistar Rats

Abstract

Aim: Ameliorative potentials of Annona muricata (Linn) on Sodium fluoride-induced toxicity on haematology indices and fecundity of adult male Wistar rats. Methods: Eighty-five (85) adult male Wistar rats were divided into 17 groups of 5 rats each. NaF (10 mg/kg) + fruit juice, ethanol stem bark, and leaf extracts of A. muricata at five different doses of 500, 1000, 1500, 2000 and 2500 mg/kg body weight were administered to the rats for 6 weeks. Blood samples were taken after 6 weeks through the ocular puncture and the sera were used for testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH) Triiodothyronine (T3), Thyroxine (T4), and Thyroid Stimulating Hormone (TSH) tests, while whole blood was used for haematological parameters such as haemoglobin (Hb), packed cell volume (PCV), total white blood cell, platelets count, lymphocytes (%) and neutrophils (%). The testes and epididymis of the rats were harvested for histological studies and sperm analysis such as sperm motility, viability, count and sperm head abnormality. Results: Administration of NaF + fruit juice, NaF + Stem bark and NaF + leaf extracts caused an increase (p<0.05) in epididymal sperm count, sperm motility, and live spermatozoa along with a

Biochemical evaluation of Ceiba pentandra leaf on the amelioration of testosterone induced-benign prostatic hyperplasia in Wister rats

“…Hormonal level of testosterone propionate-induced benign prostatic hyperplasia in male rats administered with aqueous leaf extract of C. pentandra showed a significant decrease (p > 0.05) in FSH levels for male rats in Groups 3 to 6 treated with C. pentandra compared to the negative control. This agrees with the study of Amadi et al [16] who investigated the potential ameliorative effects of aqueous leaf extract of C. pentandra. There was a decrease in testosterone and FSH concentrations in Groups 4 to 6 compared to the negative control.…”

“…The results of Amadi et al [16] who investigated the potential ameliorative effects of C. pentandra on sodium fluorideinduced toxicity on hematological indices and fecundity of adult male Wistar rats and discovered that leaf extracts of C. pentandra have no toxic effect on testes of male rats corroborated the findings of C. pentandra having no toxic effect on testes of male rats.. C. pentandra is antioxidative, anticancer, antimalarial, antihelmintic, piscicidal, antiviral, and antibacterial properties, implying a wide range of possible applications. Asimicin, bullatacin, and bullatalicin are three significant acetogenins found in ripe C. pentandra…”

“…The Effect of aqueous leaf extract of C. pentandra on hematological indices of testosterone propionate-induced benign prostatic hyperplasia in male rats showed normal hematology indices in the test groups when compared to the negative control. Previous studies have shown that some plant extracts including leaf extract of A. muricata have the potential to positively affect the erythropoietic system [16,26,27,28].…”