The potency of chitosan-Pinus merkusii extract nanoparticle as the antioxidant and anti-caspase 3 on lead acetate-induced nephrotoxicity in rat

Sudjarwo, Sri Agus; Eraiko, Koerniasari; Sudjarwo, Giftania Wardani; Koerniasari,

doi:10.4103/japtr.japtr_306_18

Cited by 15 publications

(12 citation statements)

References 17 publications

(29 reference statements)

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“…UA, SCr and BUN are renal-function indicators. In most instances, abnormal increases in the level of UA, SCr and BUN are caused by kidney damage ( Sudjarwo et al., 2019 ). The present study showed that the levels of UA, SCr and BUN in rats exposed to lead are significantly increase compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…An increase in oxidative stress also causes cell death and oxidation of macromolecule ( Sas et al., 2018 ; Bonaterra et al., 2020 ). SOD, CAT, GSH-Px are important antioxidant enzymes; they constitute a mutually supportive defense mechanism against ROS ( Sudjarwo et al., 2019 ). We showed that lead acetate could induce obvious oxidative stress in the kidneys of weaning rats ( Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…ROS overproduction can increase lipid peroxidation, and then inhibit the activity of antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase ( Navarro-Moreno et al., 2009 ). Furthermore, overproduction of free radicals induced by lead (e.g., hydroxyl radicals, superoxide anion radicals), which are highly reactive to nephron-membrane lipids and deoxyribonucleic acid (DNA), can lead to stress injuries of glomeruli and nephron tubules ( Sudjarwo et al., 2019 ). Malondialdehyde (MDA) is the main product of lipid peroxidation, which can damage biological macromolecules and be used as a biomarker of lead-induced nephrotoxicity ( Qu et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, herbal extracts based on traditional Chinese medicine (TCM) have been reported to provide protection against oxidative stress and inflammation. They have emerged as potential therapeutics to lead-induced nephrotoxicity, and the main bioactive components are flavonoids ( Wang et al., 2013 ; Sudjarwo et al., 2019 ; Rahmi et al., 2020 ). Flavonoids are a group of polyphenolic compounds, with extensive pharmacologic properties (e.g., antioxidant, anti-inflammatory, hepatoprotective, anticarcinogenic) ( Choy et al., 2019 ; Wang S. W. et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Shi

Tian

et al. 2020

Front. Pharmacol.

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Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. Smilax glabra Roxb. has been used for treatment of heavy-metal poisoning in China for 500 years. We investigated S. glabra flavonoids extract (SGF) could attenuate lead acetate-induced nephrotoxicity in weaning rats and human embryonic kidney (HEK)-293 cells, and investigated the possible mechanisms. Compared with Pb exposed group of weaning rats, SGF could significantly promote lead excretion in the blood and kidney, and increase the content of the renal-function indicators blood urea nitrogen, serum uric acid, and serum creatinine. SGF could improve the glomerular filtration rate (GFR) and histologic changes in the kidneys of weaning rats exposed to Pb. SGF could also reduce lead-induced cytotoxicity, improve DNA damage-induced apoptosis and cleaved caspase-3-mediated apoptosis in HEK-293 cells stimulated with Pb. SGF significantly increased the activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase, and decreased excessive release of reactive oxygen species (ROS) and malondialdehyde in the kidneys of the weaning rats and in HEK-293 cells. The antioxidant mechanism of SGF related to activation of the Kelch-like ECH-associated protein 1/nuclear-factor-E2-related factor 2/hemeoxygenase-1(Keap1/Nrf2/HO-1) pathway. SGF could inhibit secretion of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α induced by Pb in vivo and in vitro . The anti-inflammatory mechanism of SGF related to inhibition of ROS and pro-inflammatory cytokines triggered the nuclear factor-kappa B (NF-κB) pathway through blockade of inhibitors of I-κB degradation, phosphorylation of NF-κB p65, and nuclear translocation of p65. Our findings indicate that SGF could be a natural antioxidant and anti-inflammatory agent for treating lead-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Shi

Tian

et al. 2020

Front. Pharmacol.

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“…In addition, cyclosporine and tacrolimus cause dose-dependent afferent arteriole vasoconstrictions. [7]…”

Section: Mechanism Of Drug-induced Nephrotoxicitymentioning

confidence: 99%

Nephrotoxicity: Role and significance of renal biomarkers in the early detection of acute renal injury

Al-Naimi

Rasheed

Hussien

et al. 2019

J Adv Pharm Technol Res

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Nephrotoxicity is defining as rapid deterioration in the kidney function due to toxic effect of medications and chemicals. There are various forms, and some drugs may affect renal function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Different mechanisms lead to nephrotoxicity, including renal tubular toxicity, inflammation, glomerular damage, crystal nephropathy, and thrombotic microangiopathy. The traditional markers of nephrotoxicity and renal dysfunction are blood urea and serum creatinine which are regarded as low sensitive in the detection of early renal damage. Thus, the detection of the initial renal injures required new biomarkers which are more sensitive and highly specific that gives an insight into the site of underlying renal damage. Kidney injury molecule-1, Cystatin C, and neutrophil gelatinase-associated lipocalin sera levels are more sensitive than blood urea and serum creatinine in the detection of acute kidney injury during nephrotoxicity.

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Protective role of yeast beta-glucan on lead acetate-induced hepatic and reproductive toxicity in rats

Seven

Mutlu

Seven

et al. 2021

Environ Sci Pollut Res

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The potency of chitosan-Pinus merkusii extract nanoparticle as the antioxidant and anti-caspase 3 on lead acetate-induced nephrotoxicity in rat

Cited by 15 publications

References 17 publications

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Nephrotoxicity: Role and significance of renal biomarkers in the early detection of acute renal injury

Protective role of yeast beta-glucan on lead acetate-induced hepatic and reproductive toxicity in rats

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