The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells

Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model

“…38 Interestingly NS-1619 treatment increased survival significantly over control ( Table 1). This is consistent with our study in glioma cells 49,50 and other report 51 in human cancer cells showing NS-1619-induced apoptosis. The ability to deliver Trastuzumab by potassium channel-mediated BTB modulation in human xenografts may be clinically useful because GBMs frequently have altered receptor tyrosine kinase genes, 48 including Her-2 that is overexpressed in 17-20% of GBMs 52 resulting in poor prognosis and patient survival.…”

Expression of Ca²⁺-Activated K⁺ Channels in Human Dermal Fibroblasts and Their Roles in Apoptosis

“…In the present study, the MTT assay showed that NS1619 (a BK channel activator) decreased cell proliferation while Hoechst 33258 staining revealed that NS1619 induced early apoptotic changes, but IBTX (a specific BK channel blocker) increased cell proliferation. These results are consistent with previous reports on vascular smooth muscle cells [10,36] , hepatocytes [39] and ovarian cancer cells [40] , but do not support other reports that activation of BK channels increases cell proliferation in human endothelial cells [19] and astrocytoma cells [41] .…”

Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca2+-activated K+Channels

“…Among these paths, the large conductance Ca 2＋ -activated K ＋ (BKCa) channel has been theorized as having relevance to cell proliferation, but this assumption is still controversial [23][24][25][26][27]. Since adjuvant therapy is needed following resection of superficial bladder cancer, quercetin could be useful as adjuvant nutrition in bladder cancer treatment.…”