The Potassium Iodide Method for Determining Protection Factors in Open‐fronted Microbiological Safety Cabinets

Clark, R. P.; Goff, M. R.

doi:10.1111/j.1365-2672.1981.tb01264.x

Cited by 18 publications

(8 citation statements)

References 15 publications

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“…The concept of containment testing became generally accepted. In order to do this safely, quickly and accurately, a system known as potassium iodide (KI) Discus was developed (Clark & Goff 1981), the use of which is now incorporated into the requirements of national and international standards.…”

Section: Use Of Tracers To Mimic the Movement Of Pathogens In Healthcmentioning

confidence: 99%

Some aspects of the airborne transmission of infection

Clark¹,

Calcina-Goff²

2009

J. R. Soc. Interface.

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The relationship between the human body and the dissemination of potentially pathogenic particles and droplets is described. Airborne transmission of infection in operating theatres and a burns unit and the part played by the human microclimate and its interaction with ventilating air flows is discussed. The mechanisms by which different garment assemblies used for surgery can enhance particle dispersion are illustrated and the way that floor cleaning can increase the concentration of airborne organisms is described. The development of the successful use of ultra-clean air systems in orthopaedic implant surgery is reviewed. Relationships between contact and airborne transmission of disease are explored and ways by which containment strategies and metrics used in pharmaceutical and electronics manufacturing can be applied to the design and monitoring of healthcare areas is discussed. It is suggested that currently available techniques involving architectural, ventilation and operational aspects of healthcare provision, when properly applied, can markedly improve treatment outcomes that may otherwise be compromised by hospital-acquired infections involving both bacteria and viruses.

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Section: Use Of Tracers To Mimic the Movement Of Pathogens In Healthcmentioning

confidence: 99%

Some aspects of the airborne transmission of infection

Clark¹,

Calcina-Goff²

2009

J. R. Soc. Interface.

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“…3). The average protection factor (PF) was then evaluated from the equation PF = 62 x 105/n where n is the number in the 'count' column (Clark & Goff 1981).…”

Section: Cabinet Commissioning Testsmentioning

confidence: 99%

Open fronted safety cabinets in ventilated laboratories

Clark¹,

Osborne

Pressey³

et al. 1990

Journal of Applied Bacteriology

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Open fronted Class I and II microbiological safety cabinets (MSCs) are required by the British Standard 5726 to provide similar levels of operator protection (viz. 10(5). In laboratories that are naturally ventilated large numbers of both types of cabinets have been shown to exceed this requirement consistently over a number of years. The designs of some mechanically ventilated laboratories, however, produce excessive turbulence and draughts that can prejudice containment at the front aperture. On-site commissioning tests to determine operator protection factor are now well established and are recognized as being essential to the setting up of all open fronted cabinets in both ventilated and unventilated laboratories. This paper shows that where environmental conditions induce unsatisfactory cabinet containment, adjustments to air supply and exhaust systems can be made which will enable both Class I and II cabinets to produce operator protection factors in excess of 10(5). When compatibility is achieved between the local environment and the cabinets it is demonstrated that disturbances at the front aperture, caused by operator working procedures or by disturbances due to personnel movement within the room, have similar effects on both Class I and II cabinets. Once performance levels have been satisfactorily achieved, regular containment testing has shown that consistent performance can be maintained. These aspects of open fronted safety cabinet performance are discussed in relation to ventilated laboratories suitable for work with the human immunodeficiency virus (HIV). Of paramount importance in the future is the necessity to design laboratory air systems that will be compatible with satisfactory safety cabinet performance--a relatively new requirement in ventilation system specifications.

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“…1 Drafts, supplyair louvers, and other laminar flow equipment placed near the BSC can interfere with the containment properties of the inflow air barrier, resulting in contamination of the work environment. 63 More information on the design and use of Class II BSCs is available from the NSF International (NSF)/American National Standards Institute (ANSI) standard 49-04. 62 Recommendations for use of Class II BSCs are listed in Appendix A.…”

Section: Recommendationsmentioning

confidence: 99%

ASHP Guidelines on Handling Hazardous Drugs

2006

American Journal of Health-System Pharmacy

219

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The Potassium Iodide Method for Determining Protection Factors in Open‐fronted Microbiological Safety Cabinets

Cited by 18 publications

References 15 publications

Some aspects of the airborne transmission of infection

Some aspects of the airborne transmission of infection

Open fronted safety cabinets in ventilated laboratories

ASHP Guidelines on Handling Hazardous Drugs

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