The Post-Surgical Inflammatory Response Provokes Enhanced Tumour Recurrence: A Crucial Role for Neutrophils

Tol, M.P. van den; Raa, Sander Ten; Grevenstein, Wilhelmina M U van; Rossen, M. E. E. van; Jeekel, J.; Eijck, Casper H.J. van

doi:10.1159/000107781

Cited by 24 publications

(18 citation statements)

References 34 publications

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“…Moreover, lower infiltration of PMNs into polyp tissue was associated with growth suppression of polyps. Infiltration of PMNs into a polyp has been known to enhance tumor growth (89,90). All of these results suggest that bLF treatment can reduce the risk of colon carcinogenesis and have anti-tumor activity in humans.…”

Section: Randomized Controlled Trialsmentioning

confidence: 98%

Prevention and Intervention Trials for Colorectal Cancer

Komiya¹,

Fujii

Takahashi

et al. 2013

Japanese Journal of Clinical Oncology

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There have been a number of candidates for chemopreventive agents from synthetic drugs and natural compounds suggested to prevent colorectal cancer. However, they have shown modest efficacy in humans. The reason for this could be partly explained by the use of inappropriate models in vitro and in vivo, and the limitation of chemoprevention trials. In Japan, there are no cancer chemopreventive medicines, and few cancer chemoprevention trials to date. In contrast, an increase in the prevalence of colorectal cancer in Japan has forced us to develop more efficient chemopreventive strategies. It is now a good time to review in detail the current status and future prospects for chemoprevention of colorectal cancer with respect to the future development of chemopreventive medicines, particularly using synthetic drugs and natural compounds in Asian populations. The role and mode of action of available synthetic drugs, mainly aspirin and metformin, are reviewed. In addition, the possible impact of natural compounds with anti-inflammatory/immunosuppressive properties, such as v3 polyunsaturated fatty acid and lactoferrin, are also reviewed.

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Section: Randomized Controlled Trialsmentioning

confidence: 98%

Prevention and Intervention Trials for Colorectal Cancer

Komiya¹,

Fujii

Takahashi

et al. 2013

Japanese Journal of Clinical Oncology

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“…An acute inflammatory reaction occurs even in the absence of any apparent bacterial contamination 14 . The inflammatory sequelae after abdominal surgery promotes tumour recurrence based on the cellular component of the inflammatory process (especially neutrophils) 5,10 . Also, surgical trauma may promote tumour recurrence by producing locally active tumour-promoting agents 13,15 .…”

Section: Discussionmentioning

confidence: 99%

Peritoneal Seeding and Subsequent Progression of Mantle Cell Lymphoma after Splenectomy for Debulking

et al. 2010

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BackgroundPeritoneal seeding after abdominal surgery is a well known route of metastasis in intra-abdominal solid tumours. Direct mechanical contamination, local peritoneal trauma and subsequent inflammation, postoperative immunosuppression, and laparoscopic surgery are the proposed predisposing factors for this type of metastasis. These factors probably result in enhanced adhesion or growth of tumour cells. However, this route of metastasis has not yet been reported for lymphomas. Here, we report the first case of peritoneal seeding of lymphoma cells after an abdominal surgery. Case DescriptionA 47-year-old man with mantle cell lymphoma had ascites because of infiltration of the liver. He underwent debulking splenectomy. The postoperative ascites cytology and control abdominal computed tomography imaging both confirmed peritoneal involvement and lymphoma progression. Demonstration of negative peritoneal involvement before surgery and close timing of peritoneal involvement after splenectomy suggested to us that the debulking surgery was the main cause of peritoneal seeding of lymphoma cells in our case. ConclusionsFactors similar to those in solid tumour seeding may also be valid for lymphomas. Peritoneal seeding and consequent disease progression may be a potential complication of abdominal surgery in lymphoma with extensive intra-abdominal involvement.

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“…Patients with ovarian cancers expressing IL-1β had a 29 % death rate over 5 years vs. 1.6 % of patients whose tumours lacked IL-1β expression. Incubating colon carcinoma cells with factors released after surgical trauma (EGF and IL-1β) led to a 60 % greater cell adhesion to rat mesothelial cell monolayers [71,81]. This effect can be blocked by anti-IL-1β antibodies in a dose-dependent manner.…”

Section: Il-1β Induction Of Inflammation Cancer Cell Proliferation mentioning

confidence: 93%

“…Initial adhesion of tumour cells when introduced to the mesothelial surface is rapid, with binding to ECM proteins collagens type I and IV, laminin, fibronectin via integrins, and hyaluronan expressed on the surface of human peritoneal mesothelial cells via CD44 [73,74]. Adhesion of tumour cells is increased by peritoneal injury during open surgery [71] or by cold/dry CO 2 -pneumoperitoneum during laparoscopy [5,18,73]. Peritoneal acidosis and CO 2 insufflation results in local production of IL-1β, IL-6 and TNFα [11,14].…”

Section: Peritoneal Climate Change Favours Tumour Cell Implantation Amentioning

confidence: 99%

“…IL-1β can disrupt the integrity of human peritoneal mesothelium which leads to cell retraction and exposure of submesothelial ECM. This means that cancer cells can implant in an uninjured peritoneum when they secrete their own IL-1β, or in an accelerated way in an activated peritoneum which is expressing growth factors, cytokines, prostaglandins and adhesion molecules [71,81]. The downstream effects of VEGF are related particularly to its activation of VEGF receptor 2 tyrosine kinase (VEGFR2), leading to a cascade of activation of c-Src, FAK, Erk 1/2, Akt, mTOR in human endothelial cells.…”

Section: Interleukin-1β and Vegfmentioning

confidence: 99%

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Changes in the coelomic microclimate during carbon dioxide laparoscopy: morphological and functional implications

Wilson

2017

Pleura and Peritoneum

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In this article the adverse effects of laparoscopic CO 2 -pneumoperitoneum and coelomic climate change, and their potential prevention by warmed, humidified carbon dioxide insufflation are reviewed. The use of pressurized cold, dry carbon dioxide (C0 2 ) pneumoperitoneum causes a number of local effects on the peritoneal mesothelium, as well as systemic effects. These can be observed at a macroscopic, microscopic, cellular and metabolic level. Local effects include evaporative cooling, oxidative stress, desiccation of mesothelium, disruption of mesothelial cell junctions and glycocalyx, diminished scavenging of reactive oxygen species, decreased peritoneal blood flow, peritoneal acidosis, peritoneal hypoxia or necrosis, exposure of the basal lamina and extracellular matrix, lymphocyte infiltration, and generation of peritoneal cytokines such as IL-1, IL-6, IL-8 and TNFα. Such damage is increased by high CO 2 insufflation pressures and gas velocities and prolonged laparoscopic procedures. The resulting disruption of the glycocalyx, mesothelial cell barrier and exposure of the extracellular matrix creates a cascade of immunological and proinflammatory events and favours tumour cell implantation. Systemic effects include cardiopulmonary and respiratory changes, hypothermia and acidosis. Such coelomic climate change can be prevented by the use of lower insufflation pressures and preconditioned warm humidified CO 2 . By achieving a more physiological temperature, pressure and humidity, the coelomic microenvironment can be better preserved during pneumoperitoneum. This has the potential clinical benefits of maintaining isothermia and perfusion, reducing postoperative pain, preventing adhesions and inhibiting cancer cell implantation in laparoscopic surgery.

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The Post-Surgical Inflammatory Response Provokes Enhanced Tumour Recurrence: A Crucial Role for Neutrophils

Cited by 24 publications

References 34 publications

Prevention and Intervention Trials for Colorectal Cancer

Prevention and Intervention Trials for Colorectal Cancer

Peritoneal Seeding and Subsequent Progression of Mantle Cell Lymphoma after Splenectomy for Debulking

Changes in the coelomic microclimate during carbon dioxide laparoscopy: morphological and functional implications

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