The post-antibiotic effect of manuka honey on gastrointestinal pathogens

Lin, Shih-Min; Molan, Peter C.; Cursons, Raymond T.

doi:10.1016/j.ijantimicag.2010.06.046

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Prior works have demonstrated that honey possesses antimicrobial activity; for example, van den Berg reported that buckwheat honey exhibited significant inhibitory activity against S. aureus and E. coli [29]. Our results (Figure 4) are also consistent with the research of Lin et al showing that honey may restrain the pathogenic intestinal microbes [30]. us, we speculate that 4-hydroxybenzaldehyde, 4-hydroxy benzoic acid, and benzoic acid in buckwheat honey can inhibit precarious microorganisms.…”

Section: Discussionsupporting

confidence: 91%

Phenolics and Carbohydrates in Buckwheat Honey Regulate the Human Intestinal Microbiota

Jiang

Xie

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Intestinal microbiota plays an important role in human health. The aim of this paper is to determine the impact of the phenolics and carbohydrate in buckwheat honey on human intestinal microbiota. We investigated the phenolics and carbohydrate compositions of eight buckwheat honey samples using high-performance liquid chromatography and ion chromatography. The human intestinal microbes were cultured in a medium supplemented with eight buckwheat honey samples or the same concentration of fructooligosaccharides. The bacterial 16S rDNA V4 region sequence of DNA extraction was determined by the Illumina MiSeq platform. 12 phenolics and 4 oligosaccharides were identified in almost all buckwheat honey samples, namely, protocatechuic acid, 4-hydroxy benzoic acid, vanillin, gallic acid, p-coumaric acid, benzoic acid, isoferulic acid, methyl syringate, trans,trans-abscisic acid, cis,trans-abscisic acid, ferulic acid, 4-hydroxybenzaldehyde, kestose, isomaltose, isomaltotriose, and panose. Most notably, this is the first study to reveal the presence of 4-hydroxybenzaldehyde in buckwheat honey. 4-Hydroxybenzaldehyde seems to be a land marker of buckwheat honey. Our results indicate that buckwheat honey can provide health benefits to the human gut by selectively supporting the growth of indigenous Bifidobacteria and restraining the pathogenic bacterium in the gut tract. We infer that buckwheat honey may be a type of natural intestinal-health products.

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Section: Discussionsupporting

confidence: 91%

Phenolics and Carbohydrates in Buckwheat Honey Regulate the Human Intestinal Microbiota

Jiang

Xie

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…To date there are numerous studies that have demonstrated the therapeutic properties of Manuka honey, and have confirmed its activity against a wide range of pathogenic bacteria [21-23]. Consequently, Manuka honey has been recommended for the treatment of ailments such as leg ulcers, pilonidal sinus disease and gastrointestinal infection [24,25]. Though susceptibility of several bacterial pathogens to Manuka honey has been investigated, there is no data on C .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of Manuka honey on Clostridium difficile

Hammond

Donkor

2013

BMC Res Notes

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BackgroundManuka honey originates from the manuka tree (Leptospermum scoparium) and its antimicrobial effect has been attributed to a property referred to as Unique Manuka Factor that is absent in other types of honey. Antibacterial activity of Manuka honey has been documented for several bacterial pathogens, however there is no information on Clostridium difficile, an important nosocomial pathogen. In this study we investigated susceptibility of C. difficile to Manuka honey and whether the activity is bactericidal or bacteriostatic.MethodsThree C. difficile strains were subjected to the broth dilution method to determine minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) for Manuka honey. The agar well diffusion method was also used to investigate sensitivity of the C. difficile strains to Manuka honey.ResultsThe MIC values of the three C. difficile strains were the same (6.25% v/v). Similarly, MBC values of the three C. difficile strains were the same (6.25% v/v). The activity of Manuka honey against all three C. difficile strains was bactericidal. A dose–response relationship was observed between the concentrations of Manuka honey and zones of inhibition formed by the C. difficile strains, in which increasing concentrations of Manuka honey resulted in increasing size of zone of inhibition formed. Maximum zone of inhibition was observed at 50% (v/v) Manuka honey and the growth inhibition persisted over 7 days.ConclusionC. difficile is appreciably susceptible to Manuka honey and this may offer an effective way of treating infections caused by the organism.

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“…Methylglyoxal, the antimicrobial compound in Manuka honey, shows antibacterial activity. MGO also demonstrates this effect against bacteria with resistance to antibiotics [2][3][4].…”

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confidence: 90%