The Possible use of Autoclaving Microemulsions for Sterilization

Panaggio, Andrea; Rhodes, C. T.; Worthen, Leonard R.

doi:10.3109/03639047909055670

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…For ceftazimide, pH plays a important role in the drug stability. The pH for stability of ceftazimide was found to be pH 5.4 which is considered most favorable to prevent the degradation of drug [11]. Due to constant pH range, the drug content was found to be in acceptable limits over 3 months period of time.…”

Section: Ph Measurementmentioning

confidence: 96%

“…Ceftazidime has been shown activity against the gram-negative organisms Pseudomonas and Enterobacteriaceae. ceftazidime activity against Pseudomonas is a distinguishing feature of ceftazidime among the cephalosporins [5][6][7].…”

Section: Original Research Articlementioning

confidence: 99%

“…However, as the dose of the drug was 20 mg, the oil component was insufficient to solubilize the drug; hence Tween40 was selected as surfactant and solubilizer components, in that order. In the process of formulation, it was observed that drug precipitated in most of the microemulsion formulation formed by varying the mixtures of mentioned excipient [11,12]. For the preparation of stable ceftazidime microemulsion, complex interfacial film of combination of surfactants is favorable and therefore an amphiphilic surfactant, Epikuron®135 F having miscibility with oil, was chosen.…”

Section: Solubility Studiesmentioning

confidence: 99%

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Development and Evaluation of Ceftazidime Loaded Microemulsion for Parenteral Drug Delivery System

Hatwar¹,

Jain²,

Singhaii³

2022

JPRI

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The goal of this study was to develop a parenteral microemulsion formulation of Ceftazidime antibiotics. The ceftazidime sparingly soluble in organic solvent like ethanol, DMSO, and dimethyl formamide were determined. For biological experiment, organic solvent- free aqueous solutions of ceftazidime (hydrate) are prepared by directly dissolving the crystalline compound in aqueous buffer. The peudo ternary phase diagrams of oil, surfactant, cosurfactants (Butanol/ Isopropyl alcohol mixture) and water were constructed to identify boundaries for microemulsion existence. Ceftazidime microemulsion particle size, solution viscosity and conductivity were evaluated. The microemulsion stability and haemolytic activity were examined after dilution in 5% dextrose solution for injection to 1 mg/mL ceftazidime. In vitro haemolysis studies indicated that Ceftazidime microemulsions were well tolerated by erythrocytes. The novel microemulsion formulation of Ceftazidime was developed that is suitable for parenteral administration. This new formulation could potentially have less vehicle-associated side effects that current commercial formulation of Ceftazidime based on Cremophor® EL and isopropyl alcohol solution.

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Section: Ph Measurementmentioning

confidence: 96%

Section: Original Research Articlementioning

confidence: 99%

Section: Solubility Studiesmentioning

confidence: 99%

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Development and Evaluation of Ceftazidime Loaded Microemulsion for Parenteral Drug Delivery System

Hatwar¹,

Jain²,

Singhaii³

2022

JPRI

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“…However, at extreme temperatures, phase separation may occur but the microemulsions spontaneously return to their initial state when brought back to normal temperature and on adequate mixing. As it is established, microemulsions can be sterilized by autoclaving (12); the developed microemulsion was sterilized by autoclaving at 121°C and 15 psi for 15 min. Although there was phase separation after autoclaving, after shaking it gave a homogeneous microemulsion.…”

Section: Test For Sterilitymentioning

confidence: 99%

“…Recently, much attention has been paid to the application of microemulsions as drug delivery systems, since microemulsions are thermodynamically stable and are formed spontaneously by simple mixing of the various components (4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Formulation Development of Parenteral Phospholipid-based Microemulsion of Etoposide

2010

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The aim of the present study was to investigate the potential of a phospholipid-based microemulsion formulation for parenteral delivery of anticancer drug, etoposide. The microemulsion area was identified by constructing pseudoternary phase diagrams. The prepared microemulsions were subjected to different thermodynamic stability tests. The microemulsion formulations that passed thermodynamic stability tests were characterized for optical birefringence, droplet size, viscosity measurement, and pH measurements. To assess the safety of the formulations for parenteral delivery, the formulation was subjected to compatibility studies with various intravenous infusions and in vitro erythrocyte toxicity study. The developed formulation was found to be robust and safe for parenteral delivery.

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Physical Stability of Pharmaceutical Products

Rhodes

1979

Drug Development and Industrial Pharmacy

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A general survey of the physical stability of pharmaceutical products is presented. Some of the problems involved in this area are discussed and it is proposed that further attention should be given to the design of standardized tests for the evaluation of physical stability. NOTE -This paper is based on an invited presentation given to the Industrial Pharmaceutical Technology and Pharmaceutical Analysis and Control sections of the Academy of Pharmaceutical Sciences at Anaheim, California in April, 1979. The Academy of Pharmaceutical Sciences is to be commended on organizing this Symposium at such an appropriate time. It is the author's opinion that physical aspects of the stability of pharmaceuticals merit special attention at this juncture. We have developed a quite impressive body of knowledge of the chemical 573 Copyright 0 1979 hy Marcel Dekker, Inc. All Rights Reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/27/14 For personal use only.

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The Possible use of Autoclaving Microemulsions for Sterilization

Cited by 4 publications

References 3 publications

Development and Evaluation of Ceftazidime Loaded Microemulsion for Parenteral Drug Delivery System

Development and Evaluation of Ceftazidime Loaded Microemulsion for Parenteral Drug Delivery System

Formulation Development of Parenteral Phospholipid-based Microemulsion of Etoposide

Physical Stability of Pharmaceutical Products

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