The possible role of probiotics as dietary antimutagens

Renner, H.W.; Münzner, Ruth

doi:10.1016/0165-7992(91)90090-q

Cited by 62 publications

(21 citation statements)

References 10 publications

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“…The literature substantiating this in vitro effect has increased tremendously over the last decade. In brief, lactic acid bacteria reduce tumour cell viability (McGroatry et al, 1988;Sekine et al, 1985;Reddy et al, 1973;Reddy et al, 1983;Kato et al, 1981), suppress induced carcinogenesis in the liver and colon (Reddy & Riverson, 1993), inhibit mutagenic activity (Hosono et al, 1986;Renner & Mu Èntzner, 1991), and bind potent mutagenic metabolic compounds (Morotomi & Mutai, 1986) and food mutagen (Zhang et al, 1990). However, in spite of a wealth of indirect evidence, no direct data have yet proven cancer suppression in humans, as a result of consumption of lactic cultures in fermented or unfermented dairy products.…”

Section: Prevention Of Colonic Cancermentioning

confidence: 99%

Lactic acid bacteria and the human gastrointestinal tract

1999

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Objective: This review summarises the effects of lactic acid bacteria on lactose malabsorption, bacterialaviral or antibiotic associated diarrhoea, and describes the impact of lactic acid bacteria on cancer and the fermentative products in the colon. Results: Eight studies (including 78 patients) demonstrated that lactase de®cient subjects absorbed lactose in yogurt better than lactose in milk, while two studies (25 patients) did not support this. Two studies (22 patients) showed that unfermented acidophilus milk was absorbed better than milk, while six studies (68 patients) found no signi®cant differences. Addition of lactose hydrolysing enzyme, lactase, to milk improved lactose malabsorption in seven studies (131 lactose malabsorbers), while one study (10 malabsorbers) demonstrated no improvement. Lactic acid bacteria alleviated travellers' diarrhoea in one study (94 individuals) while a study including 756 individuals was borderline statistically signi®cant. One study (50 individuals) did not ®nd an effect of lactic acid bacteria on travellers' diarrhoea. Six studies (404 infants) demonstrated a signi®cant effect of lactic acid bacteria on infant diarrhoea, while one study (40 infants) did not. Lactic acid bacteria moderated antibiotic associated diarrhoea in three studies (66 individuals), while two studies (117 individuals) were insigni®cant. Conclusions: Lactase de®cient subjects bene®t from a better lactose absorption after ingestion of yoghurt compared with milk and from milk added lactase, whereas ingestion of unfermented acidophilus milk does not seem to improve lactose absorption. The majority of studies support that lactic acid bacteria alleviate bacterialaviral induced diarrhoea, especially in infants, while the effect on antibiotic associated diarrhoea is less clear.Experimental studies indicate an effect of lactic bacteria on human cell cancer lines, but clinical evidence is lacking. A`stabilising' effect of lactic acid bacteria on the colonic¯ora has not been documented.

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Section: Prevention Of Colonic Cancermentioning

confidence: 99%

Lactic acid bacteria and the human gastrointestinal tract

1999

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“…The animal experiments did indicate that feeding certain lactic cultures or fermented milk not only suppressed the incidence of DMH-induced colon carcinogenesis but also increased the survival rate of rats with chemically induced colon cancer [23] . These lactic cultures have been shown to possess antimutagenic properties [24] , and the probiotic was given during the initiation and promotion phases. However, the antimutagenic activity of lactic acid-producing bacteria was suspected to reside in cell wall [25] , as lactic acid itself had no antimutagenic effects [26] .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies of humans and experimental animals suggested that the influence of diet was mediated by altering the metabolic activity of intestinal bacterial flora [1,2] . Some of these enteric bacteria are beneficial to the host and have been shown to exert antimutagenic and anticarcinogenic properties [3][4][5] . By definition, probiotic bacteria can beneficially affect the host by improving its intestinal microbial balance.…”

Section: Introductionmentioning

confidence: 99%

Lack of inhibitory effects of Lactic acid bacteria on 1,2-dimethylhydrazine-induced colon tumors in rats

Li²

2003

WJG

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AIM:A myriad of healthful effects has been attributed to the probiotic lactic acid bacteria, perhaps the most controversial issue remains that of anticancer activity. This study was aimed at investigating the putative anti-cancer effects of lactic acid bacteria strains on the progression of colon tumor in 1,2-dimethylhydrazine (DMH)-treated animals. METHODS:The strain of lactic acid bacteria used in this study was lactic acid bacteria NZ9000 that conformed to the characteristics of plasmid free. Sixty male Wistar rats were given subcutaneous injections of DMH at a dose of 40 mg/kg body wt or saline once a week for 10 weeks. The rats were divided into 6 experimental groups. After the last DMH injection, animals in groups 1 and 4 were gavaged with 1 ml of lactic acid bacteria at a dose of 5×10 9 per day or vehicle until sacrifice at the end of week 22 or week 52. Animals in groups 1-3 were killed at the end of week 22 for histopathological examination. The whole period of experimental observation was 52 weeks. RESULTS:By the end of 22nd week, final average body weights of the rats treated with DMH alone and all animals receiving lactic acid bacteria were significantly decreased compared with the vehicle control (P<0.05). No differences in tumor incidence, multiplicity, dimensions and stage in the colonic mucosa were observed among the groups. At week 52, the survival rate of the rats administered lactic acid bacteria was lower than that of the rats treated with DMH that were fed on control fluids of non-lactococcus lactis. The mean survival time of lactic acid bacteria-treated animals was 39 weeks. CONCLUSION:These results indicate that lactic acid bacteria lacks inhibitory effects on the progression of colon tumor in DMH-treated animals, and does not support the hypothesis that alteration of colonic flora may exert an influence on the progression of colon tumor.Li W, Li CB. Lack of inhibitory effects of Lactic acid bacteria on 1,2-dimethylhydrazine-induced colon tumors in rats. World J Gastroenterol 2003; 9(11): 2469-2473

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“…Anti-mutagenic effect Milk cultured with Lactobacilli strains have been shown to have anti-mutagenic effects in laboratory experiments including animal studies, reducing mutagenicity and chromosome damage by approximately 80 % [6,7]. One proposed mechanism thought to be able to explain the anti-mutagenic action of lactic acid bacteria, is due to their ability to bind with these heterocyclic primary amines produced from cooked meat [8].…”

Section: Healthful Role Of Probioticsmentioning

confidence: 99%