The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice

Nikbakhsh, Rajan; Nikbakhsh, Rambod; Radmard, Mahla; Tafazolimoghadam, Armin; Haj-Mirzaian, Arvin; Pirri, Fardad; Noormohammady, Paniz; Sabouri, Maral; Shababi, Niloufar; Ziai, Seyed Ali; Dehpour, Ahmad Reza

doi:10.1016/j.biopha.2020.110453

Cited by 6 publications

(4 citation statements)

References 78 publications

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“…It has been demonstrated that naltrexone also exerts its effects as an antagonist of toll-like receptor 4 or TLR4 [26], which induce an increase in proinflammatory cytokines, substance P, nitric oxide and excitatory amino acids [27]. Moreover, a possible role of nitric oxide in the effects of naltrindole has been reported [28].…”

Section: Discussionmentioning

confidence: 99%

Antinociception induced by rosuvastatin in mice: Modulation by opioid receptor antagonists, risperidone and l-name

Juan Carlos Prieto,

Viviana Noriega,

Hugo F Miranda

2024

GSC Adv. Res. Rev.

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Statins are widely used in cardiovascular disease as cholesterol lowering drugs. However, they also have other actions (pleiotropic effects) including antiproliferative, antithrombotic, neuroprotective, immunomodulatory, anti-inflammatory and antinociceptive activity. The aim of this study was to determine the antinociception properties of rosuvastatin in two murine models of pain and the involvement of opioid antagonists (naltrexone, naltrindole, norbinaltorphimine), risperidone, and L-NAME (L-NG-nitro arginine methyl ester) in this effect. Rosuvastatin was chosen among available statins because it is commonly prescribed and has high potency, efficacy, and an acceptable safety profile. Rosuvastatin antinociception was evaluated in the acetic acid writhing test and the formalin hind paw test by dose-response curves, before and after the i.p. administration of opioid antagonists, risperidone, and L-NAME. This work demonstrates that the assayed drugs modulate the antinociceptive effect of rosuvastatin in both experimental murine pain tests. The antinociception effect described for rosuvastatin may be due to a particular modulation induced by the opioid antagonists, risperidone and L-NAME. Given the broad effects of rosuvastatin, the results of this study may have novel clinical implications in the therapy of pain.

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Section: Discussionmentioning

confidence: 99%

Antinociception induced by rosuvastatin in mice: Modulation by opioid receptor antagonists, risperidone and l-name

Juan Carlos Prieto,

Viviana Noriega,

Hugo F Miranda

2024

GSC Adv. Res. Rev.

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“…In addition to the mechanisms described, naltrexone it has been described acting as antagonists of toll-like receptor 4 (TLR4) [19], a key receptor for initiating microglial activation and for maintaining pain, especially neuropathic pain by increasing proinflammatory cytokines, substance P, nitric oxide, and excitatory amino acids [20]. Besides, a possible role of nitric oxide in the activity of naltrindole has been reported [21]. Nevertheless, naltrexone is a potent competitive inhibitor with the highest affinity for the MOR opioid receptor; however, it is a weaker antagonist of the KOR and DOR opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

Involvement of opioid antagonists on COX-2 activity

Miranda¹,

Noriega²,

Valdivia³

et al. 2023

World J. Adv. Res. Rev.

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Pain is a complex process involving complex molecular and cellular mechanisms and pharmacotherapeutic strategies including nonsteroidal anti-inflammatory drugs (NSAIDs). The main mechanism of action of them, both for their adverse and therapeutic effects, is the inhibition of cyclooxygenases (COXs), one of its isoforms is COX-2 with selective inhibitors such as celecoxib, rofecoxib, and etoricoxib. The objective of this study was to evaluate the nociceptive interaction of COX-2 NSAIDs with other drugs due to the scarce information available in this regard. Antinociception was assessed by the formalin hind paw test evaluated from dose-response curves obtained before and after the i.p. administration of 1,0 mg/kg of naltrexone (NTX), or naltrindole (NTI), or nor-binaltorphimine (nor-BNI) in the assay, using at least 6-8 animals for each of at least 4 doses. Analgesic ratio (AR) expressed as the relation between ED50 of phase II / phase I of FHP indicates the following order of relative potency: celecoxib > parecoxib > etoricoxib. Administration of naltrexone or naltrindole induced a significant reduction of the analgesic activity of celecoxib, etoricoxib and parecoxib, reflected by an increase in the respective ED50 in both phases of FHP assay. However, norbinaltorphimine lack of effect. The results of the work demonstrate that opioid receptors MOR and DOR play a key role in coxib-induced antinociception in the FHP trial and while the KOR opioid receptor seems not to be involved in this antinociception.

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“…As a primary site of memory formation and storage, hippocampus plays a critical role in addiction (Avchalumov & Mandyam, 2021). Like other forms of memory, addiction memory consolidation depends on cellular and molecular cascades, and some candidate genes are proposed in this field (Nestler, 2022). The upregulation of CREB mRNA was reported to enhance drug-related neuroadaptation in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

“…Stress exposure recruits the hippocampal μ‐opioid receptors and blocks local gamma aminobutric acid (GABA) interneurons like the action of exogenous opioid ligand on the receptors (Shi et al, 2020). Similarly, ISO rearing like DME produced convulsant activities, possibly through the recruitment of μ‐opioid receptors (Nikbakhsh et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Sarkaki

Mard

Bakhtiari

et al. 2022

Intl J of Devlp Neuroscience

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Developmental morphine (MOR) exposure (DME) detrimentally affects the cognitive abilities of the next generation. It is shown that postnatal rearing environments and prenatal conditions effectively impact memory. The present study investigated the effects of DME, postweaning rearing, and sex on spatial learning and memory. At molecular level, we evaluated mRNA levels of brainderived neurotrophic factor, cyclic AMP response element-binding protein (CREB), μ-opioid receptor, and ΔFosB in the hippocampus of male offspring. Female Wistar rats were treated with escalating doses of MOR or saline before mating, gestation, and lactation. On Postnatal Day 22, the male and female pups were divided into 12 groups and raised for 2 months under different conditions: standard, isolated (ISO), or enriched environment. Afterward, the Morris water maze task measured spatial learning and reference memory; rats were then sacrificed to assess hippocampus gene expressions. Results indicated the DME and isolated rearing increased latency to find the hidden platform in male offspring. DME was insignificant in female offspring, whereas rearing environments significantly altered escape latency in both sexes. We also found that the enriched environment upregulated the brain-derived neurotrophic factor mRNA in both saline and MOR groups, whereas it downregulated the mRNA levels of CREB1, μ-opioid receptor, and ΔFosB in the MOR group. In addition, the DME enhanced CREB1, μ-opioid receptor, and ΔFosB gene expression in the MOR + isolated group. Our findings signified the effects of DME, rearing environment, and sex on the spatial learning abilities of offspring. Also, we showed that DME and rearing conditions could manipulate hippocampal neurochemistry. K E Y W O R D S CREB, enriched environment, morphine, sex, ΔFosB, μ-opioid receptor 1 | INTRODUCTION Developmental toxic exposure has long-lasting impacts on the immature nervous system. Opioids are among the most abused drugs during pregnancy, adversely

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The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice

Cited by 6 publications

References 78 publications

Antinociception induced by rosuvastatin in mice: Modulation by opioid receptor antagonists, risperidone and l-name

Antinociception induced by rosuvastatin in mice: Modulation by opioid receptor antagonists, risperidone and l-name

Involvement of opioid antagonists on COX-2 activity

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

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