The Possible Role of Mir-1910-3p, Mir-4649-3p, Mir-4296, and Mir-210 in the Pathogenesis of Atopic Dermatitis: May Mir-4296 Play Crucial Roles in the Development of Atopic Dermatitis?

Abstract

Objective: Atopic dermatitis (AD) is a chronic inflammatory skin disease with unexplained points in its pathogenesis. Altered expressions of microRNAs (miRNA, miR) in plasma can serve as markers that distinguish diseased individuals from healthy controls AD. In the present study, plasma expression levels of miR-1910-3p, miR-4649-3p, miR-4296 and miR-210 were investigated in AD.
 Material and Methods: Forty patients with AD and forty healthy control subjects were included in the study. Quantitative real-time PCR was used to measure miRNAs.
 Results: The mean plasma miR-4296 level was significantly higher in the patient group (p < 0.001). There was a statistically significant negative correlation between SCORAD scores and miR-210 levels (r:-0.340, p=0.032). miR-210 levels decreased with increasing disease severity. In logistic regression analyses, an increase in plasma miR-4296 levels and a decrease in plasma miR-1910-3p levels were found to be statistically significant. 
 Conclusion: MiRNAs are crucial in the pathogenesis of AD. Increased miR-4296 and decreased miR-1910-3p expression levels seem to be significantly better at discriminating AD patients from healthy controls.