The possible protective role of melatonin versus garlic on monosodium Glutamate-induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscope study

El-Hay, Reem Ibrahim Abd; Mazroa, Shireen A.; El-Mohandes, E M; Moustafa, Am

doi:10.1080/01913123.2023.2175943

Cited by 1 publication

(2 citation statements)

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“…Indeed, the literature even reveals that cyclophosphamide concentration as part of the standard Bu‐Cy regimen (busulfan, cyclophosphamide) was decreased from 200 to 120 mg/kg, while busulfan doses remained unchanged 149 . The notion that testicular dysfunction progressively recovers following busulfan‐based treatment during childhood 70 is validated in murine preclinical models 134,135 …”

Section: Discussionmentioning

confidence: 99%

“…Busulfan is a component of a preparative regimen for hematopoietic cell transplantation. In prepubertal rats, a single dose of 40 mg/kg managed to impair germ, Sertoli, and Leydig cells up to 10 weeks after treatment, with a mild improvement 10 weeks later 134 . Likewise, in mice, a comparable injection of 45 mg/kg reduced germ cell count up to 8 weeks post‐treatment, with density thereafter being comparable to untreated controls.…”

Section: Preclinical Evidence Of Testicular Damagementioning

confidence: 92%

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Alkylating agents‐induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front

Sriram,

Macedo,

Mavinkurve‐Groothuis

et al. 2024

Clinical Translational Sci

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Rising cure rates in pediatric cancer patients warrants an increased attention toward the long‐term consequences of the diagnosis and treatment in survivors. Chemotherapeutic agents can be gonadotoxic, rendering them at risk for infertility post‐survival. While semen cryopreservation is an option that can be provided for most (post)pubertal boys before treatment, this is unfortunately not an option prepubertal in age, simply due to the lack of spermatogenesis. Over the last couple of years, studies have thus focused on better understanding the testis niche in response to various chemotherapeutic agents that are commonly administered and their direct and indirect impact on the germ cell populations. These are generally compounds that have a high risk of infertility and have been classified into risk categories in curated fertility guidelines. However, with it comes the lack of evidence and the challenge of using informative models and conditions most reflective of the physiological scenario, in short, the appropriate study designs for clinically relevant outcomes. Besides, the exact mechanism(s) of action for many of these “risk” compounds as well as other agents is unclear. Understanding their behavior and effect on the testis niche will pave the way for incorporating new strategies to ultimately combat infertility. Of the various drug classes, alkylating agents pose the highest risk of gonadotoxicity as per previously established studies as well as risk stratification guidelines. Therefore, this review will summarize the findings in the field of male fertility concerning gonadotoxicity of akylating agents as a result of chemotherapy exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Preclinical Evidence Of Testicular Damagementioning

confidence: 92%