The Possible Protective Role of Tannic Acid against Monosodium Glutamate-Induced Pancreatic and Liver Toxicity in Adult Male Albino Rats: Biochemical, Histological and Immunohistochemical Study

Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to monosodium glutamate

“…Similar studies demonstrated that serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), crucial indicators for diagnosing and assessing liver diseases, and apoptotic marker expression were significantly boosted in MSG‐treated rats, however, hepatic toxicity induced by MSG was ameliorated by TA. 76 , 77 Consistent with previous studies, our results show that MSG exposure has a negative effect on liver damage ( Aldoa ) and apoptotic ( Casp3 and Casp9 ) marker gene expression (Figure 6 ). ALDOA (aldolase A), a key enzyme of glycolysis metabolism, is one of the most abundant glycolytic enzymes in tumor cells and has been shown to play an important role in promoting tumor growth and metastasis in many different types of cancer.…”

“…observed that TA pretreatment reduced lipid peroxidation and blood glucose, which are increased by MSG exposure, and also significantly increased blood superoxide dismutase (SOD) levels. Similar studies demonstrated that serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), crucial indicators for diagnosing and assessing liver diseases, and apoptotic marker expression were significantly boosted in MSG‐treated rats, however, hepatic toxicity induced by MSG was ameliorated by TA 76,77 . Consistent with previous studies, our results show that MSG exposure has a negative effect on liver damage ( Aldoa ) and apoptotic ( Casp3 and Casp9 ) marker gene expression (Figure 6).…”