The possible protective role of zingerone on ethanol induced entrotoxicity of jejunum in adult albino rats: Light and scanning electron microscopic study

Abstract

Introduction: Zingerone is a nontoxic important extract of dry ginger plant. It is reported that zingerone has an anticancer property, strong anti-inflammatory and antimicrobial properties. Aim of the Work: is to evaluate the possible protective effects of zingerone on ethanol-induced lesions on the jejunum of adult male albino rats. Materials and Methods: twenty four adult male albino rats were used, divided into 3 groups; A control group (I); consisted of 8 rats, ethanol group (II); contained 8 rats and each rat given 50% v/v alcohol at a dose of 4 g/kg.bw orally for 15 days. Ethanol zingerone group (III); consisted of 8 rats, each received zingerone at a dose of 50 mg/kg and alcohol at the same previous dose daily and orally for 15 days. At the appropriate time, the specimens were taken and prepared for light and electron microscope study. Results: Histological examination of jejunum sections of ethanol group (II) showed massive jejunal villi ulcerations with shedding of their surface epithelium, loss of the villous architecture and loss of the microvilli covering some enterocytes. Examination of ethanol zingerone group (III) showed evidence of improvement in the form of nearly normal architecture of the jejunal villi with few areas of ulcerations on the top of some villi and increased cells with mitotic activity. Conclusion: Accordingly, we can conclude that zingerone administration can remarkably ameliorate ethanol-induced enterotoxiciy and jejunal ulcerations in rats by its anti-inflammatory properties and by suppressing oxidative stress.

Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

“…Zingerone contains pharmacological properties including antidiabetic, anti-inflammatory, antidiarrheic, antilipolytic, antispasmodic and anticancer properties. 114,115 Zingerone's chemoprotective properties have been observed in in vitro and in-vivo studies where it induces cell cycle arrest in neuroblastoma cells, prevents angiogenesis and its antiproliferative effects investigated in in rat colon cancer, ovarian cancer and colorectal cancer. 116,117 Zingerone possesses several pharmacological properties that render it a suitable chemopreventative and chemotherapeutic agent.…”

“…It belongs to a group of compounds called methoxyphenols where a methyl group is attached to a benzene ring. Zingerone contains pharmacological properties including antidiabetic, anti‐inflammatory, antidiarrheic, antilipolytic, antispasmodic and anticancer properties 114,115 …”