The possible protective effect of captopril on liver and bone marrow after cyclophosphamide-induced toxicity in adult albino rats

Abozaid, Samah Mohammed Mahmoud; Abobakr, Abdelhamid; Hasssan, Abil; Malak, Merry

doi:10.21608/jmr.2020.34439.1029

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Angiotension-converting enzyme inhibitor captopril (CPL) is frequently administered to treat hypertension and congestive heart failure. The beneficial effect of CPL might be through the antioxidant mechanisms, which are reportedly correlated to the drug's sulfhydryl group (SH) that directly scavenges ROS 13 . Besides, CPL increases the antioxidant enzymes and nonenzymatic antioxidant defenses 14 .…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment of the Protective Effect of N-Acetyl Cysteine and Captopril Against Cyclophosphamide-Induced Nephrotoxicity in Wistar Rats

Ali,

Mohammed

2023

Bulletin of Pharmaceutical Sciences Assiut University

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This work was executed to assess and compare the protective effect of n-acetyl cysteine (NAC) and captopril (CPL) in the nephrotoxicity induced by cyclophosphamide (CYP) in rats. Thirty-six adult male Wistar rats were separated into six groups (6 rats each). The control group received normal saline. NAC and CPL treated groups received NAC (200 mg/kg) and CPL (60 mg/kg) respectively for six consecutive days. Whereas CYP treated group received CYP (150 mg/kg) on the sixth day of the experiment. NAC+CYP and CPL+CYP treated groups received NAC and CPL respectively for 6 days then administered a single dose of CYP on the sixth day of the experiment. The intraperitoneal route is the method of administration of all drugs. CYP treated group showed a significant rise in levels of serum urea, creatinine, uric acid, and cystatin C, as also kidney MDA and IL-6 levels. Furthermore, it showed a significant decrease in kidney SOD, GSH, and IL-10 levels. Furthermore, the level of the Bcl2 gene was downregulated. Histopathological changes in the kidney exhibited marked tubular degenerative changes. Additionally, there was a significant increase in caspase-3 within the epithelium of the renal tubules. On the other hand, NAC+CYP and CPL+CYP treated groups protected against abnormal biochemical and histological changes and restored the Bcl2 gene. These data suggested that the administration of NAC and CPL could protect against CYP-induced nephrotoxic effect through their antioxidant, anti-inflammatory and anti-apoptotic effects.

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Section: Introductionmentioning

confidence: 99%

Comparative Assessment of the Protective Effect of N-Acetyl Cysteine and Captopril Against Cyclophosphamide-Induced Nephrotoxicity in Wistar Rats

Ali,

Mohammed

2023

Bulletin of Pharmaceutical Sciences Assiut University

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“…The sulfhydryl (SH) group in CAP's structure protects tissue from harm caused by oxidative stress and inflammation in many experimental models [11]. Moreover, CAP can boost the activity of antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx) [3,41]. CAP also lowers Ca + 2 levels by suppressing Ca + 2 transit through the cell membrane, preventing intracellular Ca + 2 overload and hence cell damage [2].…”

Section: Introductionmentioning

confidence: 99%

Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction

El-Ashmawy

Khedr

Shaban³

et al. 2022

Clin Phytosci

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Background Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. The initial ischemia in AMI causes biochemical and metabolic alterations in cardiomyocytes. Objectives The present study aimed to investigate the biomolecular mechanisms underlying cardioprotective effects of diallyl trisulfide (DATS) as well as captopril (CAP) in isoproterenol (ISO) induced AMI focusing on autophagy & PI3K/Akt signaling. Methods Seventy male Albino rats were divided into seven groups as follows: Normal control, ISO, ISO + LY294002 (PI3K inhibitor), DATS+ISO, CAP+ISO, DATS+LY294002 + ISO, and CAP+LY294002 + ISO. All treatments (40 mg/kg DATS, 50 mg/kg CAP & 0.3 mg/kg LY294002) were given daily for two weeks before ISO injection (85 mg/kg for 2 days). At the end of the experiment, serum and cardiac tissues were collected. Serum cardiac troponin I (cTnI), and creatine kinase MB (CK-MB) were measured. Cardiac glutathione peroxidase (GSH-px), malondialdehyde (MDA), hypoxia-inducible factor 1 alpha (HIF-1α), autophagy proteins (P62 & LC3IIB) and gene expression of PI3K, Akt, FOXO-1, and eNOS were assessed. Histopathological examination of heart tissue was performed. Results DATS and CAP significantly (p < 0.01) decreased serum CK-MB and cTnI, cardiac levels of MDA, HIF-1α, p62 and LC3IIB along with an increase in GSH-px activity compared with ISO group. Moreover, DATS and CAP significantly up-regulated PI3K, Akt, and eNOS gene expression but down-regulated FOXO-1 expression compared to ISO group. However, LY294002 reversed DATS and CAP cardioprotective effects. Conclusion DATS and CAP prior treatment proved cardioprotective effects via modulation of autophagy, PI3K/Akt signaling, eNOS and FOXO-1 downregulation in ISO induced AMI rat model.

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The possible protective effect of captopril on liver and bone marrow after cyclophosphamide-induced toxicity in adult albino rats

Cited by 2 publications

References 21 publications

Comparative Assessment of the Protective Effect of N-Acetyl Cysteine and Captopril Against Cyclophosphamide-Induced Nephrotoxicity in Wistar Rats

Comparative Assessment of the Protective Effect of N-Acetyl Cysteine and Captopril Against Cyclophosphamide-Induced Nephrotoxicity in Wistar Rats

Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction

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