The possible premalignant character of oral lichen planus and oral lichenoid lesions: A prospective five-year follow-up study of 192 patients

Meij, E.H. van der; Mast, H.; Waal, I. van der

doi:10.1016/j.oraloncology.2006.09.006

Cited by 281 publications

(231 citation statements)

References 36 publications

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“…Although there is controversy as to the potentially malignant nature of these conditions (Lodi et al, 2005;Van der Meij et al, 2007), it is generally accepted that lichen planus/lichenoid lesions can be OPMDs (Warnakulasuriya et al et al, 2007;Van der Waal, 2014). The exact mechanism that drives lichen planus/lichenoid lesions to cancer is not known, but it is believed that the chronic inflammatory microenvironment in lichen planus might cause crucial DNA damage which over time results in cancer development (Georgakopoulou et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To determine the prevalence, types, and risk factors of oral potentially malignant disorders (OPMDs) among a group of Arab Jordanian dental patients, and to evaluate their awareness and attitudes toward early diagnosis and treatment. Materials and Methods: A total of 1,041 patients attending a University Hospital for dental care were examined for the presence of OPMDs. Histopathological examination was performed on all cases clinically diagnosed and patients were directly interviewed to evaluate their knowledge and attitudes toward early detection and treatment of oral cancer. Results: The prevalence of OPMDs overall was 2.8%. Lichen planus/lichenoid lesions were the most common lesions (1.8%) followed by leukoplakias (0.48%), chronic hyperplastic candidiosis (0.38%), and erythroplakia (0.096%). Smoking, alcohol, and age (>40 years) were the main identifiable risk factors. Patients with OPMDs displayed a general lack of awareness and negative attitudes towards early diagnosis and treatment. Conclusions: OPMDs among Arab dental patients are relatively uncommon and awareness about oral cancer among Jordanian dental patients is low. Interventions to improve public knowledge about oral cancer and attitudes toward early diagnosis and treatment are urgently indicated.

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Section: Discussionmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…6 Interestingly, malignant transformations have been reported the occurrence in the OLL group during the mean follow-up of 53.8 months. 7 Thus, the relationship between medications and lesions in these two lesions are important for those patients and it will be useful for management in OLP and OLDR in the future.…”

Section: Introductionmentioning

confidence: 99%

Medications in Thai Patients with Oral Lichen Planus, Oral Lichenoid Drug Reaction and Glossitis

Nalamliang¹,

Tangnantachai²,

Thongprasom³

2014

International Journal of Experimental Dental Science

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“…[7][8][9] Lichen planus is considered as a precancerous condition. 1,6 Lichen planus is predominantly a disease of middle age. Peak incidence is reported in 3rd to 5th decade with age range of about 30 to 70 years.…”

Section: Discussionmentioning

confidence: 99%

Scanning Electron Microscopic Study of Surface Epithelial Cells in Erosive and Nonerosive Oral Lichen Planus

Thakur¹,

Hazare²

2011

The Journal of Contemporary Dental Practice

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Aim: Aim of the study is to study the surface epithelial cells of erosive, nonerosive lichen planus by scanning electron microscope (SEM) and to correlate it with that of normal mucosa and oral leukoplakia. Materials and methods:Twenty biopsies of lichen planus and five biopsies of normal mucosa were taken. Half piece of each biopsy was processed for H&E stain and another half for SEM study. Result: Surface epithelial cells were showing different features. Conclusion:Definite different features were seen in lichen planus-leukoplakia group than in normal oral mucosa. These changes are due to abnormality in cell maturation and differentiation.Clinical significance: SEM study is helpful in early detection of dysplasia. It can lead to early treatment of the lesion and thus prevention of squamous cell carcinoma.

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The possible premalignant character of oral lichen planus and oral lichenoid lesions: A prospective five-year follow-up study of 192 patients

Cited by 281 publications

References 36 publications

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Medications in Thai Patients with Oral Lichen Planus, Oral Lichenoid Drug Reaction and Glossitis

Scanning Electron Microscopic Study of Surface Epithelial Cells in Erosive and Nonerosive Oral Lichen Planus

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