The Possible Practical Implication of High CRP Levels in PCOS

Blumenfeld, Zeev

doi:10.1177/1179558119861936

Cited by 17 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High IL-6 level is associated with obesity, insulin resistance, hyperandrogenism, and ovarian dysfunction [ 1 , 7 , 28 ]. The evidence shows that CRP is associated with increased adipose tissue, obesity, dyslipidemia, and insulin resistance and is high in PCOS patients [ 1 , 12 ]. Green cardamom is an excellent source of essential oils, flavonoids, polyphenols, and sterols with analgesic, anti-inflammatory, antimicrobial and antioxidant properties [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…CRP is encoded by CRP gene and is an acute‐phase protein that is synthesized in hepatocytes by IL-6 stimulation [ 11 ]. Evidence suggests that increased TNF-α, IL-6, and CRP levels in PCOS patients indicate a low-grade chronic inflammation [ 1 , 12 ]. Therefore, dietary interventions aimed at weight loss and consequent reduced inflammation seem to be an appropriate strategy in these patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial

et al. 2021

View full text Add to dashboard Cite

Purpose Polycystic ovary syndrome (PCOS) is an endocrine disorder and a common cause of infertility among women that is associated with low-grade inflammation. Therefore, the current randomized, double-blind, placebo-controlled clinical trial was conducted to assess the effects of green cardamom supplementation on the serum level of inflammatory markers and their gene expression among obese women with PCOS. Methods We included 194 obese women with PCOS and administered low-calorie diet to all of them. These subjects were randomly divided into two groups including the intervention group with 3 g/day green cardamom ( n = 99) and the placebo group ( n = 95). Anthropometric indices, androgen hormones, and inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and C-reactive protein (CRP)] were assessed before and after the 4-month intervention. TNF-α, IL-6, and CRP gene expression levels were measured using reverse transcription-polymerase chain reaction (RT-PCR) method. Results Anthropometric indices were improved in both studied groups ( P < 0.001). Among androgen hormones, luteinizing hormone, androstenedione, and dehydroepiandrosterone were significantly decreased ( P < 0.001), and follicle-stimulating hormone was significantly increased ( P < 0.001) in the green cardamom group. Our findings showed that TNF-α, IL-6, and CRP serum levels were significantly decreased after the intervention with green cardamom plus low-calorie diet ( P < 0.001). In addition, the expression levels of TNF-α and CRP genes were significantly decreased in the intervention group ( P < 0.001). Conclusions The present study supports the beneficial anti-inflammatory effect of green cardamom on the inflammatory state in PCOS women. Level of evidence Level I: randomized clinical trial. Trial registration This trial was registered with the Iranian Clinical Trials Registry (registration number: IRCT20200608047697N1). 1 August, 2020; https://www.irct.ir/trial/48748 .

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial

et al. 2021

View full text Add to dashboard Cite

show abstract

“…CRP encoded by CRP gene is an acute-phase protein in which synthesized by IL-6 stimulation in hepatocytes [27]. Evidence shows CRP was related with increasing adipose tissue, obesity, dyslipidemia, and insulin resistance and in PCOS women is high [1,8]. Green cardamom is a good source of essential oils, flavonoids, polyphenols, and sterols that have analgesic, anti-inflammatory, antimicrobial and antioxidant properties [28].…”

Section: Discussionmentioning

confidence: 99%

“…IL-6 is also an important pro-inflammatory factor that promotes cardiovascular disease, diabetes, and allergic reactions affects the process of ovulation, implantation and fertilization [7]. Evidence suggests that increased TNF-α, IL-6, and CRP levels in the PCOS women indicate a low-grade chronic inflammation [8,1].…”

Section: Introductionmentioning

confidence: 99%

Green Cardamom Plus Low Calorie Diet Can Decrease Inflammatory Genes Expression Among Obese Women With Poly Cystic Ovarian Syndrome, A Double Blind Randomized Clinical Trial

Cheshmeh

Ghayyem

Khamooshi

et al. 2021

Preprint

View full text Add to dashboard Cite

PurposePolycystic ovary syndrome (PCOS) is a common cause of endocrine disorder and infertility among womenin which is related with low grade inflammation. Therefore, this current randomized, double-blind, placebo-controlledclinical trial assessed the effects of green cardamom supplementation on inflammatory markers and gene expressionamong obese women with PCOS.MethodsWe included 194 obese PCOS women that gave all of them low calorie diet. These subjects were randomlydivided in two studied groups including intervention with 3 g/day green cardamom (n=99) and placebo groups (n=95).Anthropometric indices, androgen hormones, and inflammatory factors (tumor necrosis factor-a (TNF-α), Interleukin6 (IL-6), and C- reactive protein (CRP)) were assessed before and after four months intervention. Their TNF-α, IL-6,and CRP genes expression level were measured using reverse transcription-polymerase chain reaction (RT-PCR)method.ResultsAnthropometric indices were improved in both two studied groups (P<0.001). Among androgen hormonesluteinizing hormone, androstenedione, and dehydroepiandrosterone were significantly decreased (P<0.001), as wellas, follicle-stimulating hormone was significantly increased (P<0.001) in the green cardamom group. Our findingsshowed that TNF-α, IL-6, and CRP serum were significantly decreased after the intervention with green cardamomplus low calorie diet (P<0.001). In addition, the expression level of TNF-α and CRP genes were significantly decreasedin intervention groups (P<0.001).ConclusionsThis present study support the beneficial anti-inflammatory effect of green cardamom on theinflammatory status in the PCOS women.Level of evidenceLevel I, randomized clinical trialTrial registrationThis trial was registered with the Iranian Clinical Trials Registry (registration number:IRCT20200608047697N1). 1 August, 2020; https://www.irct.ir/trial/48748

show abstract

“…Many studies have revealed that those with increased C-reactive protein (CRP) levels have a much higher risk of CVD, including stroke, sudden death, and peripheral vascular disease (14,15). The majority of the studies in PCOS have been shown to increase the level of CRP (15).…”

Section: Androgen Excess Society Criteriamentioning

confidence: 99%

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Ünal¹,

Demirci²,

Yılmaz³

et al. 2020

Istanbul Med J

View full text Add to dashboard Cite

Polikistik over sendromu, karotis arter intima media kalınlığı, insülin direnci, apelin, adiponektin, C-reaktif protein treatment groups (p>0.05). There was no statistically significant change in carotid IMT value in all treatment groups (p>0.05). Conclusion: According to these results, we can say that women with PCOS have subclinical atherosclerosis and that metformin treatment has a positive effect on subclinical atherosclerosis.

show abstract

The Possible Practical Implication of High CRP Levels in PCOS

Cited by 17 publications

References 26 publications

Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial

Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial

Green Cardamom Plus Low Calorie Diet Can Decrease Inflammatory Genes Expression Among Obese Women With Poly Cystic Ovarian Syndrome, A Double Blind Randomized Clinical Trial

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Contact Info

Product

Resources

About