The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis

Hasegawa-Nakamura, Kozue; Tateishi, Fumi; Nakamura, Toshiaki; Nakajima, Yasuaki; Kawamata, Kazuya; Douchi, Tsutomu; Hatae, Masayuki; Noguchi, Kazuyuki

doi:10.1111/j.1600-0765.2011.01366.x

Cited by 51 publications

(70 citation statements)

References 40 publications

(52 reference statements)

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“…Similar result also obtained in another study by Nakamura in Japan, that shows the increase of IL-8 value in the preterm labor compared to normal preterm pregnancy [8]. It was also proved in study by Yuichiro Tanaka [9] and also Marek Novak [10].…”

Section: Discussionsupporting

confidence: 85%

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Normal Pregnancy

2017

IJSR

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Abstract:Objective: This study was designed to investigate the difference of maternal serum interleukin-8 (IL-8) in preterm labor and normal pregnancy, to know the cut off point of maternal serum IL-8 in preterm labor and normal pregnancy, and also to evaluate the relative risk of preterm labor. Methods: This study was conducted in analytical cross-sectional method within September 2010 -May 2011. The inclusion sample was singleton pregnancy, within 28 -37 weeks gestational age, cervical dilation ≤ 2 cm, and willing to join the study. Results: There were 65 pregnant women, with 32 case of preterm labor and 33 control case of normal pregnancy or not in labor state. The subject characteristics such as maternal age, gestational age, and gravid status were not significantly different (p > 0.05). While the mean rate of maternal IL-8 in the preterm labor was 34.98±34.79 and the mean rate of maternal IL-8 in the normal pregnancy was 11.41±3.32, and they were significantly different (t = 3.81 and p = 0.001). Based on the analysis using ROC curve, the cut off point was 15.30 pg/ml, with sensitivity 81.8% and specificity 75%. Based on that cut off point, there was significant difference between IL-8 among two group, with x 2 = 21.104 and p = 0.001. The relative risk of preterm labor of maternal serum IL-8 > 15.30 pg/ml was 3-4 times (RR = 3.50, 95% CI = 1.86 -6.60). Conclusion: This study showed that there were no difference of the sample characteristics, with significant differences of IL-8 value between the two groups. In the ROC curve, the cut off point was 15.30 pg/ml with sensitivity 81.8% and specificity 75%. Based on that cut off point value, the relative risk of preterm labor was 3 -4 times (RR = 3.50, 95% CI = 1.86 -6.60). It could be concluded that high maternal serum IL-8 level in preterm pregnancy could induce the spontaneous preterm labor.

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Section: Discussionsupporting

confidence: 85%

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Normal Pregnancy

2017

IJSR

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“…As a periodontal pathogen, P. gingivalis may indirectly contribute to adverse pregnancy outcomes (APO) by facilitating the release of bacterial products or inflammatory mediators into the maternal circulation that reach the maternal-fetal interface [2]. P. gingivalis could also directly promote APO via invasion and injury to utero-placental tissues; this is supported by several studies that have detected P. gingivalis DNA/antigen in the placenta, amniotic fluid, umbilical cord, and neonatal nasogastric aspirates from complicated pregnancies [3][4][5][6][7][8][9][10][11]. However, the significance of P. gingivalis as a causative agent of APO is sometimes viewed with skepticism due to several confounding factors.…”

Section: Introductionmentioning

confidence: 63%

Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium considered to be an important pathogen of periodontal disease that is also implicated in adverse pregnancy outcome (APO). Until recently, our understanding of the role of P. gingivalis in APO has been limited and sometimes contradictory. The purpose of this review is to provide an overview of past and current research on P. gingivalis that addresses some of the controversies concerning the role of this organism in the pathogenesis of APO.ARTICLE HISTORY

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“…12,14 Preterm birth and low birth weight are notable health problems associated with PD, and PD related infections may lead to altered cytokine and hormone levels, which may lead to complications during pregnancy. 15,16 The biological mechanisms involved in the relationship between PDs and respiratory diseases remain unclear, but aspiration of bacteria from the oropharynx into the lower respiratory tract may be to blame. 17,18 In recent studies, the relationships between obesity, anxiety, stress, kidney disease, and periodontal health have also been investigated and there is a great deal of ongoing research in this area.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of medical doctors in Turkey about the relationship between periodontal disease and systemic health

Taşdemir

Alkan

2015

Braz. oral res.

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Understanding the relationship between periodontal disease (PD) and systemic health (SH) is necessary for the accurate diagnosis and treatment of both. The aim of this study was to evaluate the knowledge of medical doctors in Turkey with regard to the association between PD and SH. This study was carried out using self-reported questionnaires that were sent to medical doctors who work at various universities and public and private hospitals in different cities in Turkey. The questionnaires consisted of questions about the demographic information of the medical doctors, as well as the knowledge of those doctors about the relationship between PD and SH. In total, 1,766 responses were received and 90.8% of the participants agreed that there was a relationship between PD and SH. Diabetes mellitus was the most frequent systemic disease (66.8%) known to be related to PD. Of the participants, 56.5% of the medical doctors referred their patients to periodontists for different reasons. Gingival bleeding was the most frequent reason for patient referrals, with 44% of doctors giving such referrals. Doctors who worked in basic medical sciences were significantly less aware of the relationship between PD and SH than the doctors in other specialties. Although the vast majority of the medical doctors reported that they knew the relationship between PD and SH, the findings of this study showed that this awareness was not supported by precise knowledge, and often failed to translate into appropriate clinical practice.

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The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis

Abstract: Our results suggest that P. gingivalis can be detected in chorionic tissues of hospitalized high-risk pregnant women, and that P. gingivalis lipopolysaccharide induces interleukin-6 and interleukin-8 production via TLR-2 in chorion-derived cells.

Cited by 51 publications

References 40 publications

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Normal Pregnancy

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Normal Pregnancy

Porphyromonas gingivalisand adverse pregnancy outcome

Knowledge of medical doctors in Turkey about the relationship between periodontal disease and systemic health

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