The possible mechanism of <i>Datura stramonium</i> on pentobarbital-induced sleep in mice

Sobhanifar, Mohammad-Ali; Rashidi, Roghayeh; Rajabian, Arezoo; Forouzanfar, Fatemeh; Hasanpour, Maede; Iranshahi, Mehrdad; Rakhshandeh, Hassan; Hosseini, Azar

doi:10.1080/00207454.2021.1998045

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…There are also studies that call into question the safety of valerian after taking it: Sateia showed that valerian can cause mild diarrhea, Leach showed it to be relatively safe. Further clinical studies on its use and safety are needed ( 47 – 50 ).…”

Section: Discussionmentioning

confidence: 99%

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Wang

Guo

et al. 2022

Front. Nutr.

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Valerian volatile oil can be used in the treatment of insomnia; however, the active components and mechanisms of action are currently unclear. Therefore, we used transcriptome sequencing and weight coefficient network pharmacology to predict the effective components and mechanism of action of valerian volatile oil in an insomnia model induced by intraperitoneal injection of para-Chlorophenylalanine (PCPA) in SD rats. Valerian essential oil was given orally for treatment and the contents of 5-hydroxytryptamine receptor 1 A (5-HT1AR), γ-aminobutyric acid (GABA), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA) in the hippocampus of rats in each group were detected by enzyme-linked immunosorbent assay (ELISA), western blot, Polymerase Chain Reaction (PCR), and immunohistochemistry. The results showed that after treatment with valerian essential oil, insomnia rats showed significantly prolonged sleep duration and alleviated insomnia-induced tension and anxiety. Regarding the mechanism of action, we believe that caryophyllene in valerian essential oil upregulates the 5-HT1AR receptor to improve the activity or affinity of the central transmitter 5-HT, increase the release of 5-HT, couple 5-HT with a G protein coupled receptor, convert adenosine triphosphate (ATP) into cAMP (catalyzed by ADCY5), and then directly regulate the downstream pathway. Following pathway activation, we propose that the core gene protein kinase PKA activates the serotonergic synapse signal pathway to increase the expression of 5-HT and GABA, thus improving insomnia symptoms and alleviating anxiety. This study provides a theoretical basis for the application of valerian volatile oil in health food.

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Section: Discussionmentioning

confidence: 99%

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Wang

Guo

et al. 2022

Front. Nutr.

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“…In the Solanaceae family (Table S10), 4 potential plants were obtained, namely Datura stramomium L., Solanum torvum Swartz, Solanum nigrum L., and Withania somnifera (Sobhanifar et al, 2021;Mohan et al, 2013;Momin & Mohan, 2011;Siswanti, 2016;Kaur et al, 2017). D. stramomium L. and W. somnifera have antianxiety and sedative activities, while W. somnifera acts as an antidepressant.…”

Section: Scientific Evidence Indonesian Medicinal Plants Overcome Men...mentioning

confidence: 99%

Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Wati,

Batubara,

Arifin

et al. 2024

Indonesian J Pharm

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Mental health disorders are currently widely discussed, especially anxiety and depression. The number of people living with anxiety and depression disorders in 2020 increased significantly due to the COVID-19 pandemic. These mental health disorders are quite serious and need to be addressed. Indonesian people for generations have used medicinal plants in everyday life, one of which is to treat symptoms of mental health disorders such as increasing mood and motivation, calming, overcoming depression, stress, anxiety, and sleep disorders. However, there has been no comprehensive review on the ethnopharmacology of Indonesian medicinal plants that can treat mental health disorders such as depression and anxiety and there is also little scientific evidence to support the efficacy of these plants. This paper reviews Indonesian medicinal plants used to treat mental health disorders and reviews the scientific evidence for these plants. We conduct literature studies of scientific articles, research journals, and books at national and international vessels. The search results identified 67 Indonesian medicinal plants used to treat symptoms of mental health disorders. The Zingiberaceae family is reported as the most medicinal plant that can potentially treat mental health disorders such as depression and anxiety. Several plants have been proven in preclinical research, but many still have not been studied and proven. Therefore, further research on Indonesian medicinal plants that can overcome mental health disorders must be carried out to provide knowledge and develop drugs for mental health disorders.

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Oral quercetin nanoparticles in hydrogel microspheres alleviate high-altitude sleep disturbance based on the gut-brain axis

Wu,

Tang,

et al. 2024

International Journal of Pharmaceutics

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The possible mechanism of Datura stramonium on pentobarbital-induced sleep in mice

Cited by 3 publications

References 31 publications

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Indonesian Indonesian Medicine Plants for Mental Health Disorders: Anxiety and Depression

Oral quercetin nanoparticles in hydrogel microspheres alleviate high-altitude sleep disturbance based on the gut-brain axis

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