The possible influence of genetic aetiological factors on molar–incisor hypomineralisation

Hočevar, Luka; Kovač, Jernej; Podkrajšek, Katarina Trebušak; Battelino, Saba; Pavlič, Alenka

doi:10.1016/j.archoralbio.2020.104848

Cited by 27 publications

(32 citation statements)

References 45 publications

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“…Outcome . The aim of the study was to investigate the possible association between MIH and genetic or pre-, peri-, and post- natal factors [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…To investigate some genetic factors potentially involved in MIH development: in this study, SNP rs 2245803 in the MMP20 gene in a homozygous form in a recessive model was associated with MIH development [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Peri-natal factors. By comparing the results, among the most significant peri-natal causes, the following were identified as significant factors in the development of this type of injury: premature childbirth (12% of studies; this condition is correlated to the development of MIH and HPSM) [ 14 , 25 , 30 ], type of childbirth (12% of studies; this condition is correlated to the development of MIH) [ 15 , 19 , 21 ], hypoxia or respiratory problems (12% of studies; this condition is correlated to the development of MIH) [ 19 , 21 , 27 ], birth weight (8% of studies; this condition is correlated to the development of MIH and DMH) [ 27 , 29 ], and intake of vitamin D (4% of studies; this condition is correlated to the development of HPSM) [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

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Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review

Butera

Maiorani

Morandini³

et al. 2021

Children

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Objectives: Analyze defects in the state of maturation of the enamel result in an adequate volume of enamel, but in an insufficient mineralization, which can affect both deciduous teeth and permanent teeth. Among the most common defects, we recognize Deciduous Molar Hypominerlization (DMH), Hypomineralized Second Primary Molar (HSPM), and Molar Incisor Hypomineralization (MIH). These, in fact, affect the first deciduous molars, the second deciduous molars and molars, and permanent incisors, respectively, but their etiology remains unclear. The objective of the paper is to review studies that focus on investigating possible associations between genetic factors or prenatal, perinatal, and postnatal causes and these enamel defects. Materials and methods: A comprehensive and bibliometric search for publications until January 2021 was conducted. The research question was formulated following the Population, Intervention, Comparison, Outcome strategy. Case-control, cross-sectional, cohort studies, and clinical trials investigating genetic and environmental etiological factors of enamel defects were included. Results: Twenty-five articles are included. For genetic factors, there is a statistical relevance for SNPs expressed in the secretion or maturation stage of amelogenesis (16% of studies and 80% of studies that investigated these factors). For prenatal, perinatal, and postnatal causes, there is a statistical relevance for postnatal factors, such as the breastfeeding period (2%), asthma (16%), high fever episodes (20%), infections/illnesses (20%), chickenpox (12%), antibiotic intake (8%), diarrhea (4%), and pneumonia (4%). Conclusions: The results are in agreement with the multifactorial idea of the dental enamel defects etiology, but to prove this, further studies enrolling larger, well-diagnosed, and different ethnic populations are necessary to expand the investigation of the genetic and environmental factors that might influence the occurrence of DMH, HPSM, and MIH.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review

Butera

Maiorani

Morandini³

et al. 2021

Children

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“…Therefore, dental anxiety and extremely non-cooperative child behavior is fairly common in MIH [9]. In addition, three-fold to 21-fold higher protein content than sound enamel reduces the mechanical properties of enamel [10]. Adhesion of restorative materials to the hypomineralized hard dental tissue is less effective than adhesion to sound enamel [3,11].…”

Section: Introductionmentioning

confidence: 99%

“…However, it has been reported that an alteration in calcium-phosphate balance or insufficient oxygen supply to ameloblasts leads to enamel defects [12]. Some studies have explored the influence of genes and environmental factors on the occurrence of MIH [10,13]. MIH is more common in preterm children [14] and children with systemic diseases.…”

Section: Introductionmentioning

confidence: 99%

Molar Incisor Hypomineralization in Children with Intellectual Disabilities

Rajić

Modrić²,

Malčić

et al. 2021

Dentistry Journal

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The aim of the study is to compare the frequency and the distribution of molar incisor hypomineralization (MIH) in children with intellectual disabilities. Methods: Seventy-two children with intellectual disabilities and 72 healthy children were included in the study. They ranged in age from 5 to 18 years with the same distribution by age and sex. Standard clinical examination was performed, at a dental clinic or in the institution where the children lived, by using a dental mirror and a probe, according the European Academy of Paediatric Dentistry judgment criteria for MIH. Results: Among the 72 children with intellectual disabilities, eight children (11.1%) presented MIH with 19 affected teeth. In the control group, one child (1.4%) presented MIH with two affected teeth. The difference was statistically significant (p = 0.033). There were no statistically significant differences between boys and girls. The molars, especially the first right molars were the most affected tooth. Brown defects were less common than white defects. Conclusion: Children with MIH should be identified because this condition is a common problem in children with intellectual disabilities.

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Preliminary study on genetic factors related to Demirjian’s tooth age estimation method based on genome-wide association analysis

et al. 2023

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The possible influence of genetic aetiological factors on molar–incisor hypomineralisation

Cited by 27 publications

References 45 publications

Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review

Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review

Molar Incisor Hypomineralization in Children with Intellectual Disabilities

Preliminary study on genetic factors related to Demirjian’s tooth age estimation method based on genome-wide association analysis

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