The possible association betweenin vitrofertilization treatments and cancer development

Abstract

The objective of this paper is to assess whether ovarian hyperstimulation and in vitro fertilization (IVF) are associated with increased risk of cancer development, using an historical cohort analysis of infertile women who attended the IVF unit, Lis Maternity Hospital Tel Aviv Medical Center, Tel Aviv, Israel. One thousand and 82 women participated in the IVF treatment program between 1984 and 1992. Cancer incidence rates were determined through the National Cancer Registry and were compared to the expected rates with respect to appropriate age and continent of birth. Twenty-one cases of cancer were observed as compared to 11 that were expected (SIR 1.91; 95% CI 1.18–2.91). When cancer cases that were diagnosed within one year of the IVF treatment were excluded from the analysis (SIR = 1.46; 95% CI 0.83–2.36), no significant excess risk of cancer was noted. We conclude that in this cohort of infertile women, the higher than expected cancer rate could not be attributed to IVF treatments. Special attention should be made to women who may be diagnosed with cancer during or shortly after IVF treatment.

Infertility, Ovulation Induction Treatments and the Incidence of Breast Cancer—a Historical Prospective Cohort of Israeli Women

“…Although no association between infertility and breast cancer in general was previously reported by many other studies [20,21,[23][24][25][27][28][29][30][31], the current findings are in accordance with one previous publication [32].…”

“…Of them, four are case-control studies [14][15][16][17] and 15 are prospective studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. These studies are very heterogeneous; some of them referred to cohorts of women undergoing in vitro fertilizations (IVF) [26][27][28][29][30] while others referred to other types of infertility treatments [14][15][16][17][18][19][20][21][22][23], and only few studies referred to the type and dosage of fertility treatments [17, 22-24, 29, 30, 32]. Results, so far, have been inconclusive, and are summarized in Table 1.…”

Fertility drugs and the risk of breast cancer: a meta-analysis and review

“…Although several studies have been conducted to address this question, the results have been contradictory [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Therefore, the authors conducted a meta-analysis based on the current literature, results of which are reported in this article.…”

“…The subject 22 papers of this meta-analysis are described in Table 1 [6][7][8][9][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. All the 22 papers were included in the quantitative analysis.…”

Generierung und Konservierung von Keimzellen

“…In Hinblick auf die bereits eingangs erwähnte Diskussion über mögliche Risiken einer hochdosierten Gonadotropinstimulation [15], war es nahe liegend, die IVM auch bei Frauen mit unauffälligen Zyklen im Rahmen einer Kinderwunschbehandlung anzuwenden. Die hierzu vorliegenden Veröffentlichungen wurden alle mit relativ kleinen Fallzahlen durchgeführt.…”