The possibility of using amino acid supplements for stress prevention

Abstract

Every day, the modern human body is exposed to stress of various etiologies. One of the main effects of long-term stress is to accelerate the rate of premature aging. These processes affect the decrease in working capacity, reproductive capabilities, affect memory, emotions, behavior, vegetative reactions of a person, etc. The influence of unfavorable factors of professional activity (daily duty, psychoemotional overload, physical activity, violation of the diet) leads to early professional burnout. Therefore, it is important to search for and study the mechanisms of action of substances whose use for preventive purposes leads to a stable state of the body to stress. This article presents information on the study of the stress-detecting activity of a Proline-containing compound synthesized at the research Institute of pharmacology of the Russian Academy of medical Sciences. The experiment used male rats with a high level of anxiety of two ages - 3-month-old sexually Mature and 1.5-year-old. The animals were selected based on physiological tests: “Porsolt swimming test”,“open field” test. Stress was simulated by forced 30-minute swimming at a water temperature of 28-30°C. Stress-detecting mechanisms of action of the amino acid compound were evaluated by indicators of the leukocyte formula and the content of biogenic amines. It was found that the development of the strategy of adaptation to the action of a stressful factor (30-minute swimming) depends on age. In young animals, when using an amino acid compound, a hormonal type of activation of the sympathoadrenal system was noted, which is the most effective. The body of 1.5-year-old rats reacted to external influence by activating the sympathoadrenal system along the mediator pathway and entering the depletion phase. The results of this study can be the basis for the use of amino acid compounds as a functional ingredient with a stress-inducing property in the production of food in the food industry.

Evaluation of the quality, environmental safety and biological value of functional curd product

“…The use of sesame seeds in the diet improves spatial cognitive abilities, increases the concentration and activity of superoxide dismutase, catalase and glutathione peroxidase, and reduces the level of malonic dialdehyde in the hippocampus. It increases neuronal integrity, decreases the apoptotic index, decreases the expression of pro-apoptotic protein Bax and increases the expression of anti-apoptotic protein Bcl-2 in CA1 hippocampal neurons, which allows using this product in neurodegenerative diseases and encephalopathies of various genesis [9,10,11].…”

Consumer properties and environmental safety of a functional curd product

“…The use of whey proteins in nutrition leads to the normalization of blood coagulation and helps to reduce the formation of blood clots [15]. In addition, serum proteins are a source of biologically active peptides that can be used in the treatment of pathological processes such as cancer, HIV infection, hepatitis B, cardiovascular and neurodegenerative diseases, and osteoporosis [16,17,18].…”