The Possibility of electronic spectra utilization for molecular structure determination in the case of Cu(II) complexes with 2,2′-bipyridyl and o-phenanthroline

Sedov, A. L.; Dunaj‐Jurčo, M.; Kabešová, M.; Gažo, J.; Garaj, J.

doi:10.1016/s0020-1693(00)90346-3

Cited by 30 publications

(5 citation statements)

References 6 publications

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“…Measurements have been carried out using emission intensity of EB bound to DNA as a probe. EB is a weak fluorescent, but its emission intensity in the presence of DNA can be greatly enhanced because of its strong intercalation between the adjacent DNA base pairs [33]. Competitive binding to DNA of the complex with EB could provide rich information regarding DNA binding nature and relative DNA binding affinity.…”

Section: Luminescence Studiesmentioning

confidence: 99%

Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobat(II) complex

Tian

Liu

et al. 2007

Journal of Inorganic Biochemistry

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Section: Luminescence Studiesmentioning

confidence: 99%

Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobat(II) complex

Tian

Liu

et al. 2007

Journal of Inorganic Biochemistry

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“…Complex compounds CuL2(NCX)2 (where L = 2,2'-bipyridine or 1,10-phenanthroline, and X = S or Se) were prepared via processes reported in [6][7][8]. The intermediates of thermal decomposition were obtained by thermal degradation of the initial compounds in nitrogen atmosphere until the respective weight was reached (according to the thermal curves).…”

Section: Preparation Of Compoundsmentioning

confidence: 99%

“…The stabilizing effects of the bipyridine and phenanthroline ligands in the studied complexes are supported by the bonding properties of these ligands in the coordination sphere of Cu(II). From the crystal structure data [6][7][8], it follows that phenanthroline and bipyridine ligands in the Cu(II) coordination sphere each occupy one equatorial and one axial position. Such a coordination prevents the possibility of the pseudohalogenide ligand bonding via the sulphur or selenium atom, respectively, in the axial position, which is the determining factor for the start of the redox reaction in the copper(II) complexes [10].…”

Section: Thermal Properties Of Cu (Phen ) 2 ( Ncse )mentioning

confidence: 99%

Thermal properties of thio-and selenocyanatocopper(II) complexes with bipyridine and phenanthroline

Kabešová

Pirskij

Dunaj‐Jurčo

1988

Journal of Thermal Analysis

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The paper deals with the thermal properties of complex compounds of the general formula CuL2(NCX)2 (where L = bipy or phen, X = S or Se). The phenanthroline complexes exhibit a higher thermal stability than those with bipyridine. For the latter complexes thermal decomposition begins with the release of bipyridine molecules, while for the phenanthroline complexes redox ,reactions of pseudohalogenide ligands with Cu(II) take place. The redox reactions start at a lower temperature for the selenocyanate complexes than for the thiocyanate complexes.In earlier papers, the thermal properties of thiocyanatocopper(II) complexes with pyridine and all the isomeric forms of picolines and lutidines were studied [1][2][3]. It was found that the properties of the heterocyclic ligand affect the thermal stability and the stoichiometry of thermal decomposition of these complexes. Thermal decomposition begins with the release of molecules of the heterocyclic base. The release of components stabilizing the oxidation state of Cu(II), together with increased temperature, create conditions for the commencement of redox reactions between the central atom and the thiocyanate ligand. The presence of methyl substituents on the pyridine ligand decreases the thermal stability of he thiocyanate ligands, the redox reactions are shifted to lower temperatures and they are accompanied by the release of heterocyclic ligands.Likewise, it was also found that a higher number of coordinated monodentate molecules of the heterocyclic base lowers the thermal stability of the thiocyanatocopper(II) complexes [4,5].

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“…Its fluorescence intensity is very weak, but it is greatly increased when EB is specifically intercalated into the base pairs of double stranded DNA. 50 When EB is free from DNA, the fluorescence of DNA-EB complex is quenched evidently. Therefore, competitive binding to DNA of GATPT with EB could provide rich information regarding the DNA binding nature and relative DNA binding affinity.…”

Section: Gatpt-dna Interaction Spectroscopic Studiesmentioning

confidence: 99%

Design, synthesis, characterization and DNA-binding studies of a triphenyltin(iv) complex of N-glycoside (GATPT), a sugar based apoptosis inducer: in vitro and in vivo assessment of induction of apoptosis by GATPT

et al. 2012

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The novel organotin complex 1-{(2-hydroxyethyl)amino}-2-amino-1,2-dideoxy-D-glucose triphenyltin(iv) (GATPT) was synthesized by the reaction of N-glycoside ligand and triphenyltin(iv) chloride. GATPT was characterized by elemental analyses, polarimetry, IR, CD, UV and multinuclear ((1)H, (13)C, (119)Sn) 1D and 2D NMR. The interaction of GATPT with calf thymus DNA was studied by using viscometry, absorption, emission and circular dichoric spectral methods. The DNA binding results suggested the intercalative mode of binding for GATPT with DNA along with simultaneous electrostatic interaction between the Sn(iv) center and the phosphate backbone of the DNA helix. GATPT was tested for its cytotoxic properties against SY5Y, PC-12 and N2A neuronal tumor cell lines. GATPT induced significant apoptosis in the PC-12 cell line characterized by DNA fragmentation and chromosome condensation. Treatment of PC-12 cells with GATPT resulted in a dramatic up-regulation of Bax and Bak and down-regulation of the anti-apoptotic factor Bcl-2. Apoptotic induction by GATPT was shown to be mediated in a p53-dependent manner and loss of p53 impaired the release of cytochrome c from mitochondria to cytosol. Caspase-3 was found to be indispensable for the GATPT triggered apoptosis signaling pathway. Furthermore, in vivo studies using a nude mice model revealed that GATPT exhibits significant antiproliferative activity against tumor development with minimal cytotoxicity. These findings warrant further clinical investigations of GATPT as a therapeutic agent for cancer chemotherapy.

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The Possibility of electronic spectra utilization for molecular structure determination in the case of Cu(II) complexes with 2,2′-bipyridyl and o-phenanthroline

Cited by 30 publications

References 6 publications

Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobat(II) complex

Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobat(II) complex

Thermal properties of thio-and selenocyanatocopper(II) complexes with bipyridine and phenanthroline

Design, synthesis, characterization and DNA-binding studies of a triphenyltin(iv) complex of N-glycoside (GATPT), a sugar based apoptosis inducer: in vitro and in vivo assessment of induction of apoptosis by GATPT

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