The possibility of cochlear synaptopathy in young people using a personal listening device

Bal, Nilüfer; Derinsu, Ufuk

doi:10.1016/j.anl.2021.03.015

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Studies enrolling human participants in order to probe potential evidence of cochlear synaptopathy have followed several distinct approaches. The first of these approaches is enrollment of discrete groups differentiated by their history of a particular type of noise exposure ( Bramhall et al, 2017 ; Grose et al, 2017 ; Bal and Derinsu, 2021 ; Megha et al, 2021 ; Nam et al, 2021 ; Suresh and Krishnan, 2021 ). A second approach is the enrollment of diverse participants with varied amounts of lifetime noise exposures, with lifetime exposure at least roughly quantified using survey tools ( Prendergast et al, 2017a , b ; Valderrama et al, 2018 ; Marmel et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hidden hearing loss in normal-hearing firearm users

Grinn

Prell²

2022

Front. Neurosci.

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Some noise exposures resulting in temporary threshold shift (TTS) result in cochlear synaptopathy. The purpose of this retrospective study was to evaluate a human population that might be at risk for noise-induced cochlear synaptopathy (i.e., “hidden hearing loss”). Participants were firearm users who were (1) at-risk for prior audiometric noise-induced threshold shifts, given their history of firearm use, (2) likely to have experienced complete threshold recovery if any prior TTS had occurred, based on this study’s normal-hearing inclusion criteria, and (3) not at-risk for significant age-related synaptopathic loss, based on this study’s young-adult inclusion criteria. 70 participants (age 18–25 yr) were enrolled, including 33 firearm users experimental (EXP), and 37 non-firearm users control (CNTRL). All participants were required to exhibit audiometric thresholds ≤20 dB HL bilaterally, from 0.25 to 8 kHz. The study was designed to test the hypothesis that EXP participants would exhibit a reduced cochlear nerve response compared to CNTRL participants, despite normal-hearing sensitivity in both groups. No statistically significant group differences in auditory performance were detected between the CNTRL and EXP participants on standard audiom to etry, extended high-frequency audiometry, Words-in-Noise performance, distortion product otoacoustic emission, middle ear muscle reflex, or auditory brainstem response. Importantly, 91% of EXP participants reported that they wore hearing protection either “all the time” or “almost all the time” while using firearms. The data suggest that consistent use of hearing protection during firearm use can effectively protect cochlear and neural measures of auditory function, including suprathreshold responses. The current results do not exclude the possibility that neural pathology may be evident in firearm users with less consistent hearing protection use. However, firearm users with less consistent hearing protection use are also more likely to exhibit threshold elevation, among other cochlear deficits, thereby confounding the isolation of any potentially selective neural deficits. Taken together, it seems most likely that firearm users who consistently and correctly use hearing protection will exhibit preserved measures of cochlear and neural function, while firearm users who inconsistently and incorrectly use hearing protection are most likely to exhibit cochlear injury, rather than evidence of selective neural injury in the absence of cochlear injury.

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Section: Introductionmentioning

confidence: 99%

Evaluation of hidden hearing loss in normal-hearing firearm users

Grinn

Prell²

2022

Front. Neurosci.

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“…Quanto ao tipo ou desenho de estudo, verificou-se que 31 (63,2/100%) eram do tipo caso-controle e 36,7% (18/49) eram observacionais transversais. 10,11,12,14,15,16,18,19,20,21,22,23,25,26,29,31,32,33,35,37,43,44,45,46,47, 48 e 49), as definições mais utilizadas foram as de Kujawa e Liberman (1) , Makary et al (58) , Sergeyenko et al (59) e Liberman e Kujawa (60) . Segundo as definições adotadas nestes artigos, a SC seria a perda de sinapses entre as CCI e as fibras do nervo auditivo, que produz lesões em fibras de baixa taxa de descarga espontânea e alto limiar, na ausência de alteração permanente do limiar auditivo (1) .…”

Section: Características Dos Estudosunclassified

“…As principais manifestações clínicas da SC são a dificuldade de compreensão de fala no ruído, zumbido e hiperacusia na presença de audição normal (3,(5)(6)(7)(8)(9)(10)(11) . Entretanto, deve-se ressaltar que tais manifestações são comuns a variados processos patológicos auditivos e/ou otológicos e não apenas à SC.…”

Section: Introductionunclassified

“…E ainda, por ser o fator etiológico mais fundamentado desta patologia. A segunda condição mais investigada foi o zumbido (estudos 1,7,8,9,11,13,30,31,36,38,47,48), que também é apontado como um sintoma da SC. Entretanto, algumas considerações quanto a esta condição são necessárias, por se tratar de um sintoma heterogêneo em etiologia, localização, características acústicas, comorbidades associadas, entre outros (62) .…”

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Sinaptopatia coclear e perda auditiva oculta: uma revisão de escopo

Colla,

Lunardelo,

Dias

2024

CoDAS

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RESUMO Objetivo Identificar as definições fisiopatológicas adotadas pelos estudos que investigaram a “sinaptopatia coclear” (SC) e “perda auditiva oculta” (PAO). Estratégia de pesquisa Utilizou-se a combinação de unitermos “Auditory Synaptopathy” or “Neuronal Synaptopathy” or “Hidden Hearing Loss” com “etiology” or “causality” or “diagnosis” nas bases de dados EMBASE, Pubmed (MEDLINE), CINAHL (EBSCO) e Web of Science. Critérios de seleção Incluiu-se estudos que investigaram a SC ou PAO em humanos com procedimentos comportamentais e/ou eletrofisiológicos. Análise dos dados Realizou-se a análise e extração de dados quanto a terminologia, definição e população estudada. Resultados Foram incluídos 49 artigos. Destes, 61,2% utilizaram a terminologia SC, 34,7% ambos os termos e 4,1% utilizaram PAO. As condições mais estudadas foram exposição ao ruído e zumbido. Conclusão A terminologia SC foi empregada na maioria dos estudos, com referência ao processo fisiopatológico de desaferenciação entre as fibras do nervo coclear e as células ciliadas internas

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Development of an audiological assessment and diagnostic model for high occupational noise exposure

Yuan

Chen

et al. 2022

Eur Arch Otorhinolaryngol

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The possibility of cochlear synaptopathy in young people using a personal listening device

Cited by 7 publications

References 26 publications

Evaluation of hidden hearing loss in normal-hearing firearm users

Evaluation of hidden hearing loss in normal-hearing firearm users

Sinaptopatia coclear e perda auditiva oculta: uma revisão de escopo

Development of an audiological assessment and diagnostic model for high occupational noise exposure

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