The Possibility of Affecting Allergic Reactions by Histamine-Gamma-Globulin Compound

Effect of Histaglobulin in Allergic Rhinitis- A Prospective Study

“…23 There is significant improvement in radiological investigations like X-ray (PNS), after histaglobulin therapy. [9][10] There is remarkable improvement in eosinophil count when pre histaglobulin treatment and post histaglobulin treatment values were compared statistically. Immunological investigations like, serum IgE estimation (PHADIATOP TEST) improved remarkably and almost came with in normal.…”

“…After prior sensitivity tests, for drug allergy, 1 ml of subcutaneous [6][7][8][9][10][11][12][13][14][15][16] histaglobulin injection was given to the patient, 4 injections at an interval of 4 days for first month, next 4 injections at an interval of 4 days next month followed by 1 injection per month for three consecutive months and a booster dose after 6 months was given in our regime. 25 15 Patients were asked to evaluate the quality of life improvements after.…”

“…On applying statistical test to the above data, with 95% confidence interval, P<0.05 was found which is significant. [7][8][9][10][11][12][13][14][15][16][17][18][19] Graph 7…”

“…Two elements required for its development are an immunological sensitivity to an allergen and recurrent continuous exposure to it. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Although it is not a life threatening condition but significantly impair the quality of life of patients. 2 Repeated administration of an allergen extract in order to induce immunological tolerance with reduction in clinical symptoms and requirement for medication during subsequent external allergen exposure is the basis of immunotherapy in patients not responding to conventional treatment modalities.…”

“…2 Repeated administration of an allergen extract in order to induce immunological tolerance with reduction in clinical symptoms and requirement for medication during subsequent external allergen exposure is the basis of immunotherapy in patients not responding to conventional treatment modalities. [12][13][14][15][16][17][18][19][20][21][22][23][24] Histaglobulin is a sterile preparation containing histamine hydrochloride 0.15mcg, [4][5][6][7][8][9][10][11][12][13][14] human immunoglobulin 12 mg and sodium thiosulphate 32 mg dissolved in 2 ml solvent. 18 Histaglobulin from antibodies to histamine which will protect for 6-18 months against endogenous histamine.…”