The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

Zhang, Xiaoyi; Qiu, Hua; Li, Chensheng; Cai, Pingping; Qi, Fanghua

doi:10.5582/bst.2021.01318

Cited by 153 publications

(97 citation statements)

References 77 publications

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“…At this point, the effect of acupuncture on relieving symptoms may be questioned. Relevant studies have pointed out that acupuncture has synergistic and attenuating impact in managing cancer-related symptoms and adverse reactions of anticancer therapy ( 45 , 46 ). In this case, the effects of acupuncture, mecobalamin, and pregabalin are synergistic, and acupuncture can increase their efficacy in nourishing nerves and improving symptoms, which provides a reference for our clinical treatment.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment of Guillain–Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report

Liu

et al. 2022

Front. Neurol.

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Guillain–Barré syndrome(GBS) is an autoimmune-mediated peripheral neuropathy. Immune checkpoint inhibitors (ICIs) are the standard treatment for cancer and may lead to immune-related adverse events (irAEs) such as GBS. Corticosteroids, plasma exchange (PE), and intravenous immunoglobulin (IVIG) are currently accepted treatments for ICI-induced GBS. However, there are still adverse reactions, and the effect of relieving symptoms is not as good as expected. Safe and effective complementary replacement therapy to alleviate GBS symptoms and ameliorate the quality of life is urgently required. In this case, a 63-year-old man received ICI therapy and antitumor chemotherapy for lung malignancy. After two courses of treatment, the patient gradually developed limb weakness, numbness, and pain at the ends of the limbs, with cerebrospinal fluid (CSF) albuminocytological dissociation, and electromyography (EMG) suggested demyelinating changes and was diagnosed as GBS. Although the patient received high doses of intravenous gamma globulin and limb weakness symptoms were alleviated, there was still significant numbness and pain in the extremities. After four times of acupuncture treatments, the patient complained that the symptoms of limb numbness and fatigue were significantly alleviated without any discomfort. This case report may provide a new alternative and complementary therapy for immune checkpoint inhibitor-induced GBS, but more definitive and robust evidence is needed to support its efficacy.

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Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment of Guillain–Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report

Liu

et al. 2022

Front. Neurol.

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“…TCM can not only alleviate the symptoms of tumor patients and improve their quality of life but also alleviate the adverse reactions and complications caused by chemotherapy, radiotherapy or targeted therapy. 78 Evidence from preclinical studies continues to support the view that TCM is effective in preventing or mitigating side effects caused by chemotherapy. More importantly, some reported TCM have no effect on pharmacokinetics or antitumor activity of chemotherapy agents in animal experiments, suggesting that they can be used in combination with chemotherapy without reducing their efficacy.…”

Section: Discussionmentioning

confidence: 99%

Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia

Wu¹,

Dai²,

Nie³

2022

DDDT

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Tumor-associated anorexia, mainly including cancerous anorexia and chemotherapy-induced anorexia, severely reduces the life quality of cancer patients but lacks of effective control until now. Liujunzi decoction (LJZD), a classical tonifying formula in traditional Chinese medicine, has promising effect in preventing and treating many kinds of anorexia. A growing number of evidence showed that LJZD is able to improve tumor-associated anorexia. Up to March 2022, a total of 58 articles studying LJZD or Rikkunshito (the name of LJZD in Japanese herbal medicine) in the treatment of tumor-associated anorexia are searched out in PubMed. This paper summarizes the effect of LJZD in ameliorating tumor-associated anorexia, in order to provide a theoretical basis for the clinical application of LJZD in treating tumor-associated anorexia, laying foundation for further research.

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“…Worldwide traditional medicines exert alternative and supplementary roles in cancer treatment, in all of which traditional Chinese medicine (TCM) has been investigated in abundant literature. The mainstream view is that the application of TCM relieves chemotherapy- and radiotherapy-induced adverse reactions, containing gastrointestinal reactions, cardiotoxicity, and peripheral neuropathy, even acneiform eruptions and diarrhea that are EGFR-TKI related ( Zhang et al, 2021a ). The traditional decoction and botanical products from native medicine have been extensively observed and explored according to modern pharmacology and molecular sciences in carcinogenesis ( Xiang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Co-Targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: A Perspective in Ethnopharmacology

et al. 2022

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Tumor angiogenesis is one of the most important processes of cancer deterioration via nurturing an immunosuppressive tumor environment (TME). Targeting tumor angiogenesis has been widely accepted as a cancer intervention approach, which is also synergistically associated with immune therapy. However, drug resistance is the biggest challenge of anti-angiogenesis therapy, which affects the outcomes of anti-angiogeneic agents, and even combined with immunotherapy. Here, emerging targets and representative candidate molecules from ethnopharmacology (including traditional Chinese medicine, TCM) have been focused, and they have been proved to regulate tumor angiogenesis. Further investigations on derivatives and delivery systems of these molecules will provide a comprehensive landscape in preclinical studies. More importantly, the molecule library of ethnopharmacology meets the viability for targeting angiogenesis and TME simultaneously, which is attributed to the pleiotropy of pro-angiogenic factors (such as VEGF) toward cancer cells, endothelial cells, and immune cells. We primarily shed light on the potentiality of ethnopharmacology against tumor angiogenesis, particularly TCM. More research studies concerning the crosstalk between angiogenesis and TME remodeling from the perspective of botanical medicine are awaited.

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The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

Cited by 153 publications

References 77 publications

Acupuncture Treatment of Guillain–Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report

Acupuncture Treatment of Guillain–Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report

Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia

Co-Targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: A Perspective in Ethnopharmacology

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