The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons

Hasan, Mahmoud; Latifi, Shahrzad; Kahn, Cyril J.F.; Tamayol, Ali; Habibey, Rouhollah; Passeri, Elodie; Linder, Michel; Arab‐Tehrany, Elmira

doi:10.3390/md16070218

Cited by 43 publications

(33 citation statements)

References 63 publications

(68 reference statements)

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“…Liposomes with sub‐micrometer sizes are called nanoliposomes. They are around 50–200 nm in size and are extensively used for the encapsulation and controlled release systems of bioactive agents in the food, cosmetic, and pharmaceutical industries . Nanoliposomes are natural soft nanoparticles, biocompatible, biodegradable, easy‐to‐fabricate, easy‐to‐decorate, and possess low toxicity .…”

Section: Nanofunctionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

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104

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Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

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Section: Nanofunctionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

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104

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“…In fact, its poor solubility in an aqueous medium and weak stability in alkaline pH conditions or gastrointestinal fluids restrict its availability to cross into the blood circulation by oral administration. To overcome such limitations, curcumin has been previously encapsulated in polymeric nanoparticles [8], liposomes [9], biodegradable microspheres [10] and hydrogels [11,12].…”

Section: Introductionmentioning

confidence: 99%

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

et al. 2020

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Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells.

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“…Curcumin is Generally Recognized as Safe (GRAS) by the FDA, which strengthens its case as a potential natural drug [ 8 ]. However, its hydrophobic nature makes it practically insoluble in water which increases the rate of its metabolism resulting in poor bioavailability for humans after oral administration [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Loaded Nanoliposomes Localization by Nanoscale Characterization

Arab‐Tehrany

Elkhoury

Francius

et al. 2020

IJMS

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Curcumin is a hydrophobic drug gaining growing attention because of its high availability, its innocuity, and its anticancer, antitumoral, and antioxidative activity. However, its poor ‎‎bioavailability in the human body, caused by its low aqueous solubility and fast degradation, ‎‎presents a big hurdle for its oral administration. Here, we used nano-vesicles made of ‎‎phospholipids to carry and protect curcumin in its membrane. Various curcumin amounts were ‎‎encapsulated in the produced phospholipid system to form drug-loaded liposomes. ‎Curcumin’s ‎concentration was evaluated using UV-visible measurements. The maximal ‎amount of curcumin ‎that could be added to liposomes was assessed. Nuclear magnetic ‎resonance (NMR) analyses ‎were used to determine curcumin’s interactions and localization ‎within the phospholipid ‎membrane of the liposomes. X-ray scattering (SAXS) and atomic ‎force microscopy (AFM) ‎experiments were performed to characterize the membrane structure ‎and organization, as well as its ‎mechanical properties at the nanoscale. Conservation of the membrane’s properties is found with ‎the addition of curcumin in various ‎amounts before saturation, allowing the preparation of a ‎defined nanocarrier with desired ‎amounts of the drug.

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The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons

Cited by 43 publications

References 63 publications

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

Curcumin Loaded Nanoliposomes Localization by Nanoscale Characterization

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