The Positive Effects of Different Platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells

Mazzocca, Augustus D.; McCarthy, Mary Beth; Chowaniec, David M.; Dugdale, Evan M.; Hansen, David V.; Cote, Mark P.; Bradley, James P.; Romeo, Anthony A.; Arciero, Robert A.; Beitzel, Knut

doi:10.1177/0363546512452713

Cited by 175 publications

(147 citation statements)

References 34 publications

(52 reference statements)

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“…Other aspects of tissue engineering have been developed together with the development of scaffolds including stem cells and healing promotive factors 13,62 . A scaffold provides a suitable substrate for cell attachment, cell proliferation, differentiated function and cell migration.…”

Section: Optimization Of the Scaffolds As The �Inal Stepmentioning

confidence: 99%

“…Platelet-rich plasma is another healing promotive agent that initiates cell proliferation and tissue maturation 20,23,32 . These beneficial effects have been suggested to be due to the growth factors that are delivered from the platelets 62,64 . It seems that by equipping the tissueengineered scaffolds with cells and healing promotive agents, the tissueengineered graft could be optimized to open new insights in the field of tendon reconstructive surgery and regenerative medicine 12 .…”

Section: Optimization Of the Scaffolds As The �Inal Stepmentioning

confidence: 99%

See 1 more Smart Citation

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Moshiri¹,

Oryan²

2012

Hard Tissue

192

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Section: Optimization Of the Scaffolds As The �Inal Stepmentioning

confidence: 99%

Section: Optimization Of the Scaffolds As The �Inal Stepmentioning

confidence: 99%

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Moshiri¹,

Oryan²

2012

Hard Tissue

192

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“…39 PRP is safe, but effectiveness remains to be unquestionably proven. Clinical studies have shown variable results, 2,16,18,28,30 and basic science and animal studies range from positive outcomes 11,20,25,35 to suggesting little benefit for some types of injury. For example, a recent article by Delos et al 8 showed no benefit of using PRP in an animal model of contusion injury.…”

Section: Discussionmentioning

confidence: 99%

Site-specific Targeting Platelet-rich Plasma Via Superparamagnetic Nanoparticles

Lovering¹,

Vanegas²,

Pratt³

et al. 2014

Medicine & Science in Sports & Exercise

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Background: Muscle strains are one of the most common injuries treated by physicians. Standard conservative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus regarding treatments to accelerate recovery. Recently, clinical use of platelet-rich plasma (PRP) has gained momentum as an option for therapy and is appealing for many reasons, most notably because it provides growth factors in physiological proportions and it is autologous, safe, easily accessible, and potentially beneficial. Local delivery of PRP to injured muscles can hasten recovery of function. However, specific targeting of PRP to sites of tissue damage in vivo is a major challenge that can limit its efficacy.

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“…This suggests that PRP products have a positive effect on the cells' mitogenic activity. Also, improvement in collagen production and optimization of the important collagen I/III ratio have been observed 29,31,33 . However, these positive effects and their consequences for "real life" tissue healing have yet to be identified in clinical studies 3 .…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal stem cell response to growth factor treatment and low oxygen tension in 3-dimensional construct environment

Durant

Dyment

McCarthy

et al. 2014

MLTJ

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SummaryStudies using in vitro cell models enable evaluation of the effects of different PRP products under very controlled and standardized conditions. Therefore the results of such studies build the basis for understanding the variable results of clinical studies on the use of PRPs. The main lessons learned through the use of in vitro cell models are that many different PRP products exist and researchers have to report on component variation within each product. These different products may have distinctive effects on the various cells treated in musculoskeletal injuries; therefore, some products might be more beneficial in certain indication than others. In its utilization in cell models, PRP may generate a variety of positive effects on cell proliferation, recovery, and inflammatory response. There might also be a benefit to adding PRP to current pharmacological therapies (e.g. corticosteroids) to prevent their commonly known negative effects on e.g. tendon and cartilage tissue.

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The Positive Effects of Different Platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells

Abstract: The utilization of different PRP separations may result in a potentially beneficial effect on the clinically relevant target cells in vitro, but it is unclear which platelet concentration or PRP preparation may be optimal for the treatment of various cell types.

Cited by 175 publications

References 34 publications

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: Current concepts, approaches and concerns

Site-specific Targeting Platelet-rich Plasma Via Superparamagnetic Nanoparticles

Mesenchymal stem cell response to growth factor treatment and low oxygen tension in 3-dimensional construct environment

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