The positive effect of soybean protein hydrolysates—calcium complexes on bone mass of rapidly growing rats

Abstract

It was previously found that soybean protein hydrolysates (SPHs) can bind with calcium to form soluble complexes and promote calcium uptake by Caco-2 cells. However, the role of SPHs-calcium complexes on bone mass still needs to be explored. Fast growing male and female rats (n = 72) were assigned to eight groups: Control, lactic acid calcium (LCa), SPHs-calcium complexes (SPHCa) and casein phosphopeptides calcium (CPPCa). After four weeks treatment, oral administration of SPHCa significantly increased femur BMD of rats compared with Control and LCa groups (P < 0.05), while there are no obvious difference on the BMD of femur and lumbar vertebrae between SPHCa and CPPCa groups. Also, SPHCa showed a tendency to improve the mechanical properties of vertebra lumber for female rats. These findings suggest that the SPHs-calcium complexes might have positive effects on bone accretion of fast growing animals. This study brings new insight for better understanding the role of soybean protein itself on bone mass.

Soybean peptide aggregates improved calcium binding capacity

“…In the same manner, soybean protein hydrolysates (SPHs) were reported to promote calcium uptake by Caco-2 cells (Lv, Bao, Yang, Ren, & Guo, 2008). A recent study suggested that the SPHsecalcium complexes might have positive effects on bone accretion of fast growing animals (Lv, Liu, Ren, Li, & Guo, 2013).…”

Assessing the Effects of Dietary Inclusion of Hydrolyzed Soy Protein on the Growth, Nutrient Retention, Body Composition, and Serum Hormone of Juvenile Starry Flounder, Platichthys stellatus

“…It was notable that inclusion of HSP (10–30%) also improved the ash content of whole fish. This finding indicates that HSP promote the deposition of minerals in the bone of juvenile fish through iron‐chelating activity of peptides (Lv et al ). It has been reported that soy peptide could bind with minerals to form soluble complexes and promote their uptake (Lv et al ).…”

Preparation and Characterization for Peptide-Chelated Calcium of Deer Bone

“…Until now, it has been demonstrated that the peptide-chelated calcium might be a typical calcium fortifier to improve bone health of human body. For example, several investigators had suggested that the peptides from whey protein (Xixi et al, 2015), fish scales (Guo et al, 2015, Chen et al, 2014 and soybean (Bao et al, 2008, Lv et al, 2013b could chelate with Ca 2+ and the reaction products were stable in the gastrointestinal tract to promote calcium absorption in vivo. Actually, the deer bone is rich in collagen which can be hydrolyzed into peptides, but there were little studies about the peptides from deer bone chelated with Ca 2+ as calcium fortifier.…”