The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement

Abstract

Background: The mTOR signaling pathway is inactivated by AMPK’s tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers. Methods: This study investigated the clinical data about prostate cancer. Examination was also carried out into tissue microarrays (TMA) of human prostate cancer (n = 382) and adjacent non-neoplastic tissues around prostate cancer (n = 61). The TMA slides were incubated with antibodies against UBE2O, and the cores were scored by the pathologist blind to cancer results. Results: Very strong positive correlations were identified between the expression of UBE2O staining and high PSA and pathological stage of prostate cancer. Cox’s proportional hazard analysis established correlations between the following: (1) positive surgical margin and biochemical recurrence free survival, (2) PSA grade and clinical recurrence free survival, (3) regional lymph node positive and clinical recurrence free survival, (4) adjuvant treatment and overall survival, and (5) pathological T stage and overall survival. Conclusion: There is a positive correlation between the expression of UBE2O staining and prognosis for prostate cancer. Thus, a prostate cancer prognosis can be assessed with the expression of UBE2O staining.

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“…UBE2O promotes the proliferation, EMT, and stemness properties of breast cancer cells through the UBE2O/AMPKalpha2/mTORC1-MYC positive feedback loop ( 29 ). A positive correlation was reported between the expression of histopathological UBE2O staining and prostate cancer advancement ( 30 ). UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPK/mTOR pathway ( 31 ).…”

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“…UBE2O, an E2/E3 hybrid enzyme, can modulate its substrate through mono-ubiquitination, multisite mono-ubiquitination, or polyubiquitination ( 50 , 57 , 58 ). Previous studies have shown that UBE2O plays an oncogenic role in diverse cancers, such as breast cancer ( 59 ), prostate cancer ( 60 ), liver cancer ( 61 ), and lung cancer ( 52 ), etc. However, Xu et al.…”