The Position of the Heart During Normothermic Ex Situ Heart Perfusion is an Important Factor in Preservation and Recovery of Myocardial Function

Hatami, Sanaz; Xiao, Qi; White, Christopher W.; Bozso, Sabin J.; Himmat, Sayed; Sergi, Consolato; Nagendran, Jayan; Chung, Hyun‐Joong; Nobes, David S.; Freed, Darren H.

doi:10.1097/mat.0000000000001386

Cited by 4 publications

(3 citation statements)

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“…[13][14][15][16] The reproducibility of pig models has also permitted investigation into optimal donor organ preservation. 17,18 Studies using large animal models for donor organ research can be grouped into three distinct categories. In the first category (Table 2A) are studies evaluating hemodynamic, metabolic, and hormonal changes associated with brain death and the effects of brain death on donor organ function [19][20][21][22][23][24][25] or pharmacologic interventions to mitigate the adverse effects of brain death.…”

Section: Introductionmentioning

confidence: 99%

“…In the context of transplantation research, porcine models are an essential research tool to optimize organ procurement practices and serve important roles in procedural refinement, mechanistic investigation, and surgical team cohesion (Table 1). 13‐16 The reproducibility of pig models has also permitted investigation into optimal donor organ preservation 17,18 …”

Section: Introductionmentioning

confidence: 99%

“… 13 , 14 , 15 , 16 The reproducibility of pig models has also permitted investigation into optimal donor organ preservation. 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

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Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

Heinis,

Merani,

Markin

et al. 2024

Anim Models and Exp Med

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Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia–reperfusion injury, organ preservation strategies, and future donor‐based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice. We present an overview of two porcine models of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD). The cardiovascular anatomy and physiology of pigs closely resembles those of humans, making this species the most appropriate for pre‐clinical research. Pigs are also considered a potential source of organs for human heart and kidney xenotransplantation. It is imperative to minimize animal loss during procedures that are surgically complex. We present our experience with these models and describe in detail the use cases, procedural approach, challenges, alternatives, and limitations of each model.

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