The position of the gene locus for monocyte alloantigens (HMA system) on chromosome 6

Abstract

In ten families with 65 children (with 64 informative meioses), a close linkage between the monocyte antigen locus (HMA) and HLA was found with a recombination frequency of 1.56%.

Recombination within the class III region by a double cross over event

“…Between HLA-B and C2, the genes for the aand P-chain of the tumor necrosis factor (TJYF) are located (Ragoussis et a 1987). In direct neighborhood to the MHC, two distinct gene loci defined a monocyte-specific alloantigen system (= HMA-A and -B, Rose 1987, Rose & Menzel 1988. Double crossing over events have been observed in only two cases, including GLO as the outer marker (Hawkins et al 1980).…”

Report of the committee on the genetic constitution on chromosome 6

“…The two loci determining the HLA-linked monocytic alloantigen system are designated HMAA and HMAB (Rose and Menzel, 1988). The HMMA locus determines four serologically defined antigens and the HMMB locus three.…”