2008
DOI: 10.1038/nrmicro1994
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The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

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Cited by 753 publications
(783 citation statements)
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References 94 publications
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“…Both efflux pumps and porins contribute to microbial resistance to toxic compounds, such as antibiotics (Davin-Regli et al 2008;Delcour 2009;Pages et al 2008). In the study by Khudyakov et al, some of the efflux pumps and porins were up-regulated and down-regulated, respectively, in E. lignolyticus cells exposed to…”
Section: Elucidating Mechanisms Of Il Tolerancementioning
confidence: 99%
“…Both efflux pumps and porins contribute to microbial resistance to toxic compounds, such as antibiotics (Davin-Regli et al 2008;Delcour 2009;Pages et al 2008). In the study by Khudyakov et al, some of the efflux pumps and porins were up-regulated and down-regulated, respectively, in E. lignolyticus cells exposed to…”
Section: Elucidating Mechanisms Of Il Tolerancementioning
confidence: 99%
“…The lack of new drugs combined with the rapid spread of resistant organisms poses a tremendous challenge for medical research and practice in the 21 st century. Antibiotic resistance develops in a number of ways: the lipid membrane can act as a barrier preventing the accumulation of the drug in the cell, the drugs might be enzymatically decomposed, the drug targets can be modified; in many cases multiple mechanisms are active simultaneously 3,4 . A better understanding of drug transport across lipid membranes is highly desirable and could facilitate the development of the next generation of antibiotics.…”
Section: Introductionmentioning
confidence: 99%
“…First steps in this direction are already under active development [113]. It is also conceivable that these experiments would help investigations about antibiotics transport into bacteria [114,115].…”
Section: Future Perspectivesmentioning
confidence: 99%