The Porcine Retinal Vasculature Accessed Using an Endovascular Approach: A New Experimental Model for Retinal Ischemia

Morén, Håkan; Undrén, Per; Gesslein, Bodil; Olivecrona, Göran; Andréasson, Sten; Malmsjö, Malin

doi:10.1167/iovs.09-3529

Cited by 17 publications

(16 citation statements)

References 24 publications

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“…The mechanism underlying ischemic retinal degeneration and potential protective interventions are studied in a diversity of animal models (Dimitriu et al 2008;Moren et al 2009;Osborne et al 2004;Vidal-Sanz et al 2000). Similar to cerebral ischemia, the extent and degree of retinal ischemic damage largely depends on the model used and the animal strain and gender (Barnett and Osborne 1995;Davidson et al 2000;Mester et al 2009;Oliff et al 1997;Yamamoto et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

et al. 2011

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Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroprotective peptide exerting protective effects in neuronal injuries. We have provided evidence that PACAP is neuroprotective in several models of retinal degeneration in vivo. Our previous studies showed that PACAP treatment ameliorated the damaging effects of chronic hypoperfusion modeled by permanent bilateral carotid artery occlusion. We have also demonstrated in earlier studies that treatment with PACAP antagonists further aggravates retinal lesions. It has been shown that PACAP deficient mice have larger infarct size in cerebral ischemia. The aim of this study was to compare the degree of retinal damage in wild type and PACAP deficient mice in ischemic retinal insult. Mice underwent 10 min of bilateral carotid artery occlusion followed by 2-week reperfusion period. Retinas were then processed for histological analysis. It was found that PACAP deficient mice had significantly greater retinal damage, as shown by the thickness of the whole retina, the morphometric analysis of the individual retinal layers, and the cell numbers in the inner nuclear and ganglion cell layers. Exogenous PACAP administration could partially protect against retinal degeneration in PACAP deficient mice. These results clearly show that endogenous PACAP reacts as a stress-response peptide that is necessary for endogenous protection against different retinal insults.

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Section: Introductionmentioning

confidence: 99%

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

et al. 2011

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“…In contrast to humans and nonhuman primates, mice lack a macular region. In contrast to previous studies, 8,9 we obtained mfERG responses from areas that could be identified on a retinal image using the SLO. By centering some hexagons of the multifocal stimulus on the ONH and on photocoagulations, we were able to establish a correlation between morphological and functional characteristics.…”

Section: Discussionmentioning

confidence: 99%

Multifocal ERG Recordings Under Visual Control of the Stimulated Fundus in Mice

Dutescu

Skosyrski

Kociok

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…In a porcine model of retinal ischemia, ERG was shown to develop decreased amplitude and increased latency, during balloon occlusion of the retinal artery supply. [8] Additionally, total obliteration of retinal perfusion (including collateral circulation) resulted in complete loss of ERG signals. Others have used combined ERG and VEP monitoring during ophthalmic artery surgery and demonstrated the reproducibility of intraoperative ERG recording.…”

Section: Discussionmentioning

confidence: 99%

Electroretinography during embolization of an ophthalmic arteriovenous fistula

Padalino

Melnyk²,

Allott³

et al. 2013

Surg Neurol Int

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Background:Intraoperative neuromonitoring (IONM) is used for real-time evaluation of neuronal tracts and reflexes in the anesthetized patient, when a neurologic exam is not possible. Changes in IONM signals forewarn of possible neurological deficit. This real-time feedback allows for immediate alterations in therapeutic technique by the treating physician. Transcranial visual evoked potentials are not reliable for evaluating the integrity of the prechiasmatic visual system. Electroretinography (ERG) has been used in animal models for monitoring retinal ischemia and can be used in humans as well to monitor for prechiasmatic ischemia of the retinae and optic nerves.Case Description:We present a case where ERG signal amplitude and latency changed during ophthalmic arteriovenous fistula embolization, resulting in an intraprocedural decision to refrain from embolization of additional arterial pedicles to preserve vision. After awakening from general anesthesia, the patient had no deficits in visual acuity or field testing, but did complain of transient pain with eye movement that resolved the next day and worsened with episodes of blood pressure elevation.Conclusions:ERG may be helpful for detecting prechiasmatic ischemic changes during endovascular procedures and may provide early warning signs to the surgeon before the onset of permanent retinal damage. Further investigation is needed to assess the utility of ERG monitoring during the treatment of orbital and periorbital vascular lesions.

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The Porcine Retinal Vasculature Accessed Using an Endovascular Approach: A New Experimental Model for Retinal Ischemia

Abstract: The authors show for the first time that the ophthalmic and retinal artery can be catheterized using a transfemoral endovascular approach. This technique may be useful to produce clear-cut experimental retinal ischemia.

Cited by 17 publications

References 24 publications

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

Multifocal ERG Recordings Under Visual Control of the Stimulated Fundus in Mice

Electroretinography during embolization of an ophthalmic arteriovenous fistula

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