The porcine erythropoietin gene: cDNA sequence, genomic sequence and expression analyses in piglets

David, R.B.; Blom, Anne Kristine; Sjaastad, Ø. V.; Harbitz, I.

doi:10.1016/s0739-7240(01)00089-3

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…The duration of ischaemia thus is within a window, where infarct reduction should be possible in the model. Porcine EPO (David et al, 2001) and receptor (Pearson et al, 2000) and corresponding human counterparts, show a high degree of similarity. Importantly, rhEPO has been documented to be effective in pigs regarding haematopoietic effects (Emery et al, 1996;Kovacevic et al, 1999), as well as regarding endothelial biological response (Vogel et al, 1997), documenting that rhEPO is biologically operative at pig EPO receptors.…”

Section: Discussionmentioning

confidence: 99%

Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model

Kristensen¹,

Mæng

Rehling³

et al. 2005

Clin Physio Funct Imaging

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Section: Discussionmentioning

confidence: 99%

Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model

Kristensen¹,

Mæng

Rehling³

et al. 2005

Clin Physio Funct Imaging

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“…The amino-acid identity between pig and human erythropoietin (produced by the kidney) is approximately 82%. 18,69 Life-supporting pig-to-NHP renal xenotransplantation was associated with the gradual development of normocytic, normochromic anemia in the absence of treatment with recombinant human erythropoietin. 64 This effect possibly resulted from molecular incompatibility between pig erythropoietin and the primate erythropoietin receptor.…”

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confidence: 99%

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

2018

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Xenotransplantation can provide a solution to the current shortage of human organs for patients with terminal renal failure. The increasing availability of genetically engineered pigs, effective immunosuppressive therapy, and antiinflammatory therapy help to protect pig tissues from the primate immune response and can correct molecular incompatibilities. Life-supporting pig kidney xenografts have survived in NHP for more than 6 mo in the absence of markers of consumptive coagulopathy. However, few reports have focused on the physiologic aspects of life-supporting pig kidney xenografts. We have reviewed the literature regarding pig kidney xenotransplantation in NHP. The available data indicate (1) normal serum creatinine, (2) normal serum electrolytes, except for a trend toward increased calcium levels and a transient rise in phosphate followed by a fall to slightly subnormal values, (3) minimal or modest proteinuria without hypoalbuminemia (suggesting that previous reports of proteinuria likely were due to a low-grade immune response rather than physiologic incompatibilities), (4) possible discrepancies between pig erythropoietin and the primate erythropoietin receptor, and (5) significant early increase in kidney graft size, which might result from persistent effects of pig growth hormone. Further study is required regarding identification and investigation of physiologic incompatibilities. However, current evidence suggests that, in the absence of an immune response, a transplanted pig kidney likely would satisfactorily support a human patient.

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“…The nucleotide sequences of full-length EPO cDNA have been reported for humans, 2 macaques, 10 cattle, 12 pigs, 13 and rats, 15 and the nucleotide sequences of partial EPO cDNA have been reported for rhesus monkeys, 11 dogs, 11 cats, 11 and rabbits. 14 Furthermore, the partial genomic DNA sequence of eEPO has been described as a part of intron 1 and exon 2.…”

Section: Discussionmentioning

confidence: 99%

“…It stimulates erythrocytic progenitors in bone marrow to induce proliferation and differentiation of stem cells to develop into erythrocytes. [7][8][9] The nucleotide sequence of EPO has been reported for humans, 2 macaques, 10 rhesus monkeys, 11 cattle, 12 pigs, 13 dogs, 11 cats, 11 rabbits, 14 and rats. However, increased RBC mass induced by the administration of rhEPO increases aerobic capacity and can improve athletic performance.…”

Section: E Rythropoietin (Epo) Is a Glycoprotein Hormonementioning

confidence: 99%

Nucleotide sequence of equine erythropoietin and characterization of region-specific antibodies

Sato

Yamashita²,

Kugo³

et al. 2004

ajvr

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The porcine erythropoietin gene: cDNA sequence, genomic sequence and expression analyses in piglets

Cited by 13 publications

References 30 publications

Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model

Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

Nucleotide sequence of equine erythropoietin and characterization of region-specific antibodies

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