The population structure, antimicrobial resistance, and pathogenicity of Streptococcus suis cps31

Wang, Xiaoming; Sun, Jianzhong; Bian, Chen; Wang, Jianping; Liang, Zijing; Shen, Yanling; Yao, Huochun; Huang, Jinhu; Wang, Liping; Zheng, Han; Wu, Zongfu

doi:10.1016/j.vetmic.2021.109149

Cited by 17 publications

(42 citation statements)

References 29 publications

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“…The zebrafish infection model was first used to evaluate the virulence of strain WUSS351. The LD 50 value of strain WUSS351 was 1.1 × 10 6 CFU/fish, similar to that of the virulent control strain SC070731 [ 14 , 33 ] (8.6 × 10 5 CFU/fish). Then, their virulence was further determined in a mouse infection model.…”

Section: Resultssupporting

confidence: 60%

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The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

Liang

Bian

et al. 2022

Virulence

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Section: Resultssupporting

confidence: 60%

“…The Reed and Muench method [ 32 ] was used to calculate the lethal dose (LD) 50 . A highly virulent S. suis strain, serotype 2 meningitis isolate SC070731, was used as a positive control [ 14 , 33 ]. A BALB/c mouse infection model was also used to further evaluate the virulence of strain WUSS351.…”

Section: Models Of Animal Infectionmentioning

confidence: 99%

The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

Liang

Bian

et al. 2022

Virulence

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“…Most virulence-associated genes preferentially present in highly pathogenic S. suis serotype 2 strains were absent from all serotype 7 genomes. Previous studies also reported that these virulence markers studied in S. suis serotype 2 strains were not suitable as virulence markers for S. suis non-serotype 2 strains [ 3 , 12 , 44 ]. Thus, S. suis serotype 7 virulent strains may utilize a different pathogenesis strategy.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-seven ICEs carrying AR genes were found in S. suis serotype 7 genomes, although intact prophages carrying AR genes were not detected. Conversely, AR genes in S. suis serotype 31 population were majorly present in prophages [ 12 ]. In the present study, two types of DNA cargo of IMEs and CIMEs with AR genes were integrated into genes SNF2 or PPI of all ICEs.…”

Section: Discussionmentioning

confidence: 99%

“…Serotype 9 has become the most prevalent serotype in diseased pigs in some European counties [ 1 , 10 ], and one human case of serotype 9 infection was reported [ 11 ]. Serotypes 4, 5, 16, 21, 24, and 31 have also been reported in human infections [ 1 , 12 ]. Serotype 7 is an important serotype frequently isolated from diseased pigs in European countries, North America, and Thailand [ 13–18 ], and it was also related to severe herd problems of meningitis and arthritis in nursery and grower pigs [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs

Liang

Wang

Gottschalk

et al. 2021

Emerging Microbes & Infections

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Streptococcus suis is one of the important emerging zoonotic pathogens. Serotype 2 is most prevalent in patients worldwide. In the present study, we first isolated one S. suis serotype 7 strain GX69 from the blood culture of a patient with septicemia complicated with pneumonia in China. In order to deepen the understanding of S. suis serotype 7 population characteristics, we investigated the phylogenetic structure, genomic features, and virulence of S. suis serotype 7 population, including 35 strains and 79 genomes. Significant diversities were revealed in S. suis serotype 7 population, which were clustered into 22 sequence types (STs), five minimum core genome (MCG) groups, and six lineages. Lineages 1, 3a, and 6 were mainly constituted by genomes from Asia. Genomes of Lineages 2, 3b, and 5a were mainly from Northern America. Most of genomes from Europe (41/48) were clustered into Lineage 5b. In addition to strain GX69, 13 of 21 S. suis serotype 7 representative strains were classified as virulent strains using the C57BL/6 mouse model. Virulence-associated genes preferentially present in highly pathogenic S. suis serotype 2 strains were not suitable as virulence indicators for S. suis serotype 7 strains. Integrative mobilizable elements were widespread and may play a critical role in disseminating antibiotic resistance genes of S. suis serotype 7 strains. Our study confirmed S. suis serotype 7 is a non-negligible pathotype and deepened the understanding of the population structure of S. suis serotype 7, which provided valuable information for the improved surveillance of this serotype.

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Bacterial and host factors involved in zoonotic Streptococcal meningitis

Ma,

Wu,

et al. 2024

Microbes and Infection

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The population structure, antimicrobial resistance, and pathogenicity of Streptococcus suis cps31

Cited by 17 publications

References 29 publications

The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils

Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs

Bacterial and host factors involved in zoonotic Streptococcal meningitis

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