The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens

Wilson, Benjamin A.; Garud, Nandita R.; Feder, Alison F.; Assaf, Zoe June; Pennings, Pleuni S.

doi:10.1111/mec.13474

Cited by 44 publications

(32 citation statements)

References 211 publications

(438 reference statements)

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“…In fact, multidrug resistant strains have been observed with increasing frequency and their spreading has been recognized as one of the most alarming issues for the global health system, resulting in high levels of morbidity and mortality (Wilson et al, 2016). Infections caused by staphylococcal and enterococcal are reported as a major problem in hospitalized patients especially those using indwelling medical devices such as urinary catheters, feeding tubes, and peripherally inserted central catheters (Padmavathy et al, 2015; Tong et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

et al. 2016

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Bacterial resistance to the available marketed drugs has prompted the search of novel therapies; especially in regards of anti-virulence strategies that aim to make bacteria less pathogenic and/or decrease their probability to become resistant to therapy. Cinnamaldehyde is widely known for its antibacterial properties through mechanisms that include the interaction of this compound with bacterial cell walls. However, only a handful of studies have addressed its effects on bacterial virulence, especially when tested at sub-inhibitory concentrations. Herein, we show for the first time that cinnamaldehyde is bactericidal against Staphylococcus aureus and Enterococcus faecalis multidrug resistant strains and does not promote bacterial tolerance. Cinnamaldehyde actions were stronger on S. aureus as it was able to inhibit its hemolytic activity on human erythrocytes and reduce its adherence to latex. Furthermore, cinnamaldehyde enhanced the serum-dependent lysis of S. aureus. In vivo testing of cinnamaldehyde in Galleria mellonella larvae infected with S. aureus, showed this compound improves larvae survival whilst diminishing bacterial load in their hemolymph. We suggest that cinnamaldehyde may represent an alternative therapy to control S. aureus-induced bacterial infections as it presents the ability to reduce bacterial virulence/survival without promoting an adaptive phenotype.

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Section: Introductionmentioning

confidence: 99%

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

et al. 2016

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“…Comparing blood samples from before the start of treatment and after treatment had failed, they found that patients with resistance mutations present as SGV were more likely to fail treatment due to resistance evolution (see also Wilson et al . ). Another study (Jabara et al .…”

Section: Evidencementioning

confidence: 97%

“…Paredes et al (2010) determined whether resistance mutations were already present as SGV in the viral population of 183 patients. Comparing blood samples from before the start of treatment and after treatment had failed, they found that patients with resistance mutations present as SGV were more likely to fail treatment due to resistance evolution (see also Wilson et al 2016). Another study (Jabara et al 2011) looked only at one patient, but did very deep and accurate sequencing.…”

Section: I C R O B E Smentioning

confidence: 99%

Soft sweeps and beyond: understanding the patterns and probabilities of selection footprints under rapid adaptation

2017

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Summary1. The tempo and mode of adaptive evolution determine how natural selection shapes patterns of genetic diversity in DNA polymorphism data. While slow mutation-limited adaptation leads to classical footprints of 'hard' selective sweeps, these patterns are different when adaptation responds quickly to a novel selection pressure, acting either on standing genetic variation or on recurrent new mutation. In the past decade, corresponding footprints of 'soft' selective sweeps have been described both in theoretical models and in empirical data. 2. Here, we summarize the key theoretical concepts and contrast model predictions with observed patterns in Drosophila, humans, and microbes. 3. Evidence in all cases shows that 'soft' patterns of rapid adaptation are frequent. However, theory and data also point to a role of complex adaptive histories in rapid evolution. 4. While existing theory allows for important implications on the tempo and mode of the adaptive process, complex footprints observed in data are, as yet, insufficiently covered by models. They call for in-depth empirical study and further model development.Key-words: adaptation, Drosophila, genetic hitch-hiking, HIV, lactase, malaria, selective sweep Hard and soft selective sweeps

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“…Notably, it is the only other Leptinotarsa species known to host on >3 genera of plants, and suggests that heterozygosity might be an important feature for host expansion or a consequence of greater niche breadth (Kassen 2002). Levels of heterozygosity, or standing genetic variation, have been linked to rapid adaptive evolution in a variety of study systems (Messer and Petrov 2013), including other cases of repeatedly evolving to toxic environments (Whitehead et al 2017; Wilson et al 2016). Importantly, it may be directly linked to our second mechanism of rapid adaptation, the rate of positive selection on protein-coding genes, as populations with high standing variation typically have higher rates of adaptive evolution (Barrett and Schluter 2008; Hermisson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Elevated rates of positive selection drive the evolution of pestiferousness in the Colorado potato beetle (Leptinotarsa decemlineata, Say)

Cohen

Brevik

Chen

et al. 2019

Preprint

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19Insect pests are characterized by expansion, preference and performance on agricultural 20 crops, high fecundity and rapid adaptation to control methods, which we collectively refer to as 21 pestiferousness. Which organismal traits and evolutionary processes facilitate certain taxa 22 becoming pests remains an outstanding question for evolutionary biologists. In order to 23 understand these features, we set out to test the relative importance of genomic properties that 24 underlie the rapid evolution of pestiferousness in the emerging pest model: the Colorado potato 25 beetle (CPB), Leptinotarsa decemlineata Say. Within the Leptinotarsa genus, only CPB has 26 risen to pest status on cultivated Solanum. Using whole genomes from ten closely related 27 Leptinotarsa species, we reconstructed a high-quality species tree of this genus. Within this 28 phylogenetic framework, we tested the relative importance of four drivers of rapid adaptation: 29 standing genetic variation, gene family expansion and contraction, transposable element 30 variation, and protein evolution. Throughout approximately 20 million years of divergence, 31 Leptinotarsa show little evidence of gene family turnover or transposable element variation 32 contributing to pest evolution. However, there is a clear pattern of pest lineages experiencing 33 greater rates of positive selection on protein coding genes, as well as retaining higher levels of 34 standing genetic variation. We also identify a suite of positively selected genes unique to the 35 Colorado potato beetle that are directly associated with pestiferousness. These genes are 36 involved in xenobiotic detoxification, chemosensation, and hormones linked with pest behavior 37 and physiology.38 39

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The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens

Cited by 44 publications

References 211 publications

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Soft sweeps and beyond: understanding the patterns and probabilities of selection footprints under rapid adaptation

Elevated rates of positive selection drive the evolution of pestiferousness in the Colorado potato beetle (Leptinotarsa decemlineata, Say)

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