The polymorphism -863C/A in tumour necrosis factor-  gene contributes an independent association to gout

Abstract

The genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption.

Relationship between -238A/G and -308A/G polymorphisms in the promoter region of TNF-α and susceptibility to gout in the Chinese Han male population

“…Therefore, we could not conclude that polymorphisms TNF-α-238A/G and -308A/G are associated with gout. Our results are consistent with the study of Chang et al [10] on the relationship between the polymorphism of -308A/G and -863C/A in TNF-α and gout in male Taiwanese. They showed that polymorphism -863C/A in TNF-α was significantly associated with gout, and showed a significant association between the genotype AA of polymorphism -863C/A and the development of gout; however, no association was found for polymorphism -308A/G.…”

“…However, no association was found for polymorphism -308A/G [10]. Therefore, in the present study, we investigated whether polymorphisms -238A/G and -308A/G in the promoter region of TNF-α are associated with susceptibility to gout in the Chinese Han male population.…”

Gout patients have an increased risk of developing most cancers, especially urological cancers

“…Inflammation has been found to be related to several cancers, including colorectal (1), pancreatic (2), urinary bladder (3), and renal clear cell cancer (4). In our previous studies we have shown that the occurrence of gout is associated with the cytokine genes that are involved in the inflammation mechanism, including the tumour necrosis factor (TNF)-α gene (5), cyclic GMP-dependent protein kinase (cGK)II gene (6), interleukin (IL)-6 gene (7), and the transforming growth factor (TNF)-β1 gene (8), along with IL-8 and IL-12 (9). These molecules had also been found to be overexpressed in prostate, lung, gastric, breast, colorectal, renal, and other tumours, and are associated with the clinical and pathological features of cancer and with patient survival (10)(11)(12)(13)(14).…”

Polymorphisms −1082 G/A and −819 C/T in the Interleukin-10 Gene Are Not Associated with Gout Susceptibility in the Chinese Han Male Population

“…Because the capacity for cytokine production in individuals largely depends on genetic polymorphisms (Landis and Haskard, 2001) and heterogeneity of the candidate gene in patients with gout emerges as a probable biomarker for determining the disease phenotypes, much previous research has focused on the association between polymorphisms of cytokine genes and gout. IL-6 -174G/C, -597G/A, the transforming growth factor b1 (TGF-b1) 869T/C, and TNF-a -863C/A were found to be associated with gout (Chang et al, 2007Chang et al, 2007;Reuss et al, 2002), while IL-6 -572C/G or -373A/T, TGF-b1 -509C/T, and TNF-a -308 A/G polymorphism are not related to gout (Chang et al, 2007;Chang et al, 2008;.…”