The polymorphic markers of the XRCC1, ERCC5, TP53, CDKN1A1 genes and the survival of triple negative breast cancer patients after platinum-based chemotherapy.
Abstract:e12556 Background: Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. There are no special targets for neoadjuvant therapy of TNBC, and leading treatment for TNBC is chemotherapy including the regiments with platinum drugs. The aim of the work was to study the relationship between the polymorphic markers rs25487 of the XRCC1 gene, rs17655 of the ERCC5 gene, rs1042522 of the TP53 gene, rs1801270 of the CDKN1A1 gene with progression-free (PFS) and overall survival (OS) in pati… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.