Abstract. We study the interpolation property of Sobolev spaces of order 1 denoted by W 1 p,V , arising from Schrödinger operators with positive potential. We show that for 1 ≤ p 1 < p < p 2 < q 0 with p > s 0 , W 1 p,V is a real interpolation space between W 1 p1,V and W 1 p2,V on some classes of manifolds and Lie groups. The constants s 0 , q 0 depend on our hypotheses.