The Pocked Erythrocyte

Holroyde, Christopher P.; Oski, Frank A.; Gardner, Frank H.

doi:10.1056/nejm196909042811002

Cited by 114 publications

(17 citation statements)

References 11 publications

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“…In individuals with a dysfunctional or absent spleen the membrane of erythrocytes appears to contain so called “pits” when studied with interference phase microscopy [20]. With electron microscopy it was shown that these “pits” are in fact large vacuoles (about 300 nm in diameter) beneath or attached to the plasma membrane.…”

Section: Approaches To Measuring Splenic Functionmentioning

confidence: 99%

Assessment of splenic function

Porto

Lammers

Bennink

et al. 2010

Eur J Clin Microbiol Infect Dis

156

142

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Hyposplenic patients are at risk of overwhelming post-splenectomy infection (OPSI), which carries mortality of up to 70%. Therefore, preventive measures are warranted. However, patients with diminished splenic function are difficult to identify. In this review we discuss immunological, haematological and scintigraphic parameters that can be used to measure splenic function. IgM memory B cells are a potential parameter for assessing splenic function; however, more studies are necessary for its validation. Detection of Howell–Jolly bodies does not reflect splenic function accurately, whereas determining the percentage of pitted erythrocytes is a well-evaluated method and seems a good first-line investigation for assessing splenic function. When assessing spleen function, 99mTc-labelled, heat-altered, autologous erythrocyte scintigraphy with multimodality single photon emission computed tomography (SPECT)-CT technology is the best approach, as all facets of splenic function are evaluated. In conclusion, although scintigraphic methods are most reliable, they are not suitable for screening large populations. We therefore recommend using the percentage of pitted erythrocytes, albeit suboptimal, as a first-line investigation and subsequently confirming abnormal readings by means of scintigraphy. More studies evaluating the value of potentially new markers are needed.

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Section: Approaches To Measuring Splenic Functionmentioning

confidence: 99%

Assessment of splenic function

Porto

Lammers

Bennink

et al. 2010

Eur J Clin Microbiol Infect Dis

156

142

View full text Add to dashboard Cite

show abstract

“…Human erythrocytes are not usually thought of in the context of phagocytosis or pinocytosis; however, in certain circumstances endocytosis can be seen in circulating human erythrocytes (3)(4)(5). A variety of agents (6) can induce membrane internalization in vitro in inReceived for publication 10 May 1974 and in revised form 12 March 1975. tact human erythrocytes and the extent of endocytosis correlates directly with cellular youth and with the energy metabolism of the red cell, as represented particularly by its ATP content (7).…”

Section: Introductionmentioning

confidence: 99%

Energized endocytosis in human erythrocyte ghosts.

Schriei¹,

Bensch²,

Johnson³

et al. 1975

J. Clin. Invest.

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“…The red cells from normal newborns are slightly more resistant to osmotic lysis than those of adults, whereas the mechanical fragility of cord blood red cells is increased [20]. Red cells from both prema ture and term infants display a 'pocked' ap pearance in the interference phase micros copy [21 ], which is believed to reflect the pres ence of vacuoles and internal structures just below the red cell membrane [22]. Such cells were observed in greater numbers among very preterm infants.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Li+i-Na+o Countertransport in the Newborn

Agam

Deutsch²,

Karplus³

et al. 1993

Neonatology

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The present study investigates the erythrocyte Li_i⁺-Na_o⁺ countertransport (CT) in the newborn. Erythrocytes of term infants exhibit no or very low CT activity at birth (0.025 ± 0.011 mmol Li/1 RBC·h). CT rates increase gradually and reach adult values within the 4th-7th day of life (0.225 ± 0.018 mmol Li/1 RBC·h). CT activity in healthy preterm infants at birth is not significantly different from that in term infants (0.014 ± 0.007 mmol Li/1 RBC·h). Postnatal maturation of CT activity in preterm infants is similar to that found in term infants and is independent of gestational age. However, CT rates at birth of premature infants subjected to prenatal stress are significantly higher (0.082 ± 0.017 mmol Li/1 RBC·h). It is concluded that erythrocyte CT activity in the newborn reaches adult values within the first week of life, apparently reflecting the postnatal maturation of the CT system in the cell membrane. We suggest that prenatal stress induces the synthesis of the CT protein in utero.

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The Pocked Erythrocyte

Cited by 114 publications

References 11 publications

Assessment of splenic function

Assessment of splenic function

Energized endocytosis in human erythrocyte ghosts.

Erythrocyte Li<sup>+</sup><sub>i</sub>-Na<sup>+</sup><sub>o</sub> Countertransport in the Newborn

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