“…It has been reported that the inflammatory cells including macrophages, lymphocytes, and eosinophils express PLXNC1 (Esnault et al, 2014;Konig et al, 2014), suggesting that SEMA7A contributes to the infiltration by not only neutrophils but also macrophages, lymphocytes, and eosinophils in the lungs of IgE-sensitized mice. However, in the airway inflammation by the coadministration of IL-33 and IL-17A, the treatment with anti-SEMA7A antibody did not suppress the infiltration by macrophages and lymphocytes in BALF, although neutrophils and eosinophils were inhibited.…”