The Plasmodium falciparum family of Rab GTPases

Quévillon, Emmanuel; Spielmann, Tobias; Brahimi, Karima; Chattopadhyay, Debasish; Yeramian, Edouard; Langsley, Gordon

doi:10.1016/s0378-1119(03)00381-0

Cited by 81 publications

(97 citation statements)

References 32 publications

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“…A prerequisite for the parasite differentiation and rapid growth during the liver phase is an extensive intracellular remodelling. Signalling via Rab proteins and the formation and transport of vesicles are thought to play key roles in these processes and might represent potent targets for intervention in the parasite's life cycle (Quevillon et al, 2003). Identification of other key signalling events during the liver phase and/or proteases initiating parasite liberation at the end of the liver stage would also be important for understanding hepatocyte infection and subsequent potential applications, such as development of new anti-malarial strategies at a very early and non-pathogenic infection phase in hepatocytes.…”

Section: Intra-hepatocyte Developmentmentioning

confidence: 99%

“…Plasmodium parasites clearly posses a classical secretory pathway: Rab GTPases are well-established regulators of vesicular traffic in eukaryotes, and a family of Plasmodium Rabs has been described (Quevillon et al, 2003;Langsley et al, 2008). When not associated with a vesicle, Rabs are bound to a carrier protein called rabGDI, a homologue of which has also been described in P. falciparum (Attal & Langsley, 1996).…”

Section: Membrane Dynamics and Traffickingmentioning

confidence: 99%

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Signalling in malaria parasites – The MALSIG consortium

et al. 2009

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Summary :Depending on their developmental stage in the life cycle, malaria parasites develop within or outside host cells, and in extremely diverse contexts such as the vertebrate liver and blood circulation, or the insect midgut and hemocoel. Cellular and molecular mechanisms enabling the parasite to sense and respond to the intra-and the extra-cellular environments are therefore key elements for the proliferation and transmission of Plasmodium, and therefore are, from a public health perspective, strategic targets in the fight against this deadly disease. The MALSIG consortium, which was initiated in February 2009, was designed with the primary objective to integrate research ongoing in Europe and India on i) the properties of Plasmodium signalling molecules, and ii) developmental processes occurring at various points of the parasite life cycle. On one hand, functional studies of individual genes and their products in Plasmodium falciparum (and in the technically more manageable rodent model Plasmodium berghei) are providing information on parasite protein kinases and phosphatases, and of the molecules governing cyclic nucleotide metabolism and calcium signalling. On the other hand, cellular and molecular studies are elucidating key steps of parasite development such as merozoite invasion and egress in blood and liver parasite stages, control of DNA replication in asexual and sexual development, membrane dynamics and trafficking, production of gametocytes in the vertebrate host and further parasite development in the mosquito. This article, which synthetically reviews such signalling molecules

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Section: Intra-hepatocyte Developmentmentioning

confidence: 99%

Section: Membrane Dynamics and Traffickingmentioning

confidence: 99%

Signalling in malaria parasites – The MALSIG consortium

et al. 2009

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“…La famille entière des Rab de P. falciparum vient d'être décrite avec dix gènes exprimés dans les érythro-cytes infectés et un gène (Pfrab11b) qui semble spéci-fique d'un autre stade de développement du parasite (voir Tableau II, pour les fonctions potentielles) [26]. Les Rab sont associées aux membranes après prénylation de leur extré-mité carboxyterminale (des di-peptides CXC ou CC) par une enzyme parasitaire [27].…”

Section: Régulation Du Trafic Protéines Rabunclassified

“…La famille Rab étant limitée à onze gènes chez P. falciparum, P. berghei et S. cerevisiae, et à sept gènes chez S. pombe, une comparaison entre les trois espèces peut permettre de cerner la fonction d'une protéine Rab du parasite [26]. Pour démontrer l'homologie entre les Rab du parasite (P. falciparum et P. berghei) et les deux espèces de levure, nous avons construit une arbre phylogé-nique (Figure 2).…”

Section: Fonctions Potentielles Des Rabunclassified

“…Il est donc possible que PfRab7 joue un rôle dans la régulation de la taille, soit de la vacuole parasitophore (VP) entourant le parasite, soit de la vacuole digestive; l'expression tardive du gène dans le globule rouge infecté conforte cette idée [26]. , avec comme out-group la Rho6 humaine, comme nous l'avons déjà décrit pour P. falciparum [26]. [32].…”

Section: Fonctions Potentielles Des Rabunclassified

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Trafic protéique dans le globule rouge infecté parPlasmodium

Baunaure

Langsley

2005

Med Sci (Paris)

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Tetrahymena thermophila: A divergent perspective on membrane traffic

Briguglio

Turkewitz

2014

J Exp Zool Pt B

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Tetrahymena thermophila, a member of the Ciliates, represents a class of organisms distantly related from commonly used model organisms in cell biology, and thus offers an opportunity to explore potentially novel mechanisms and their evolution. Ciliates, like all eukaryotes, possess a complex network of organelles that facilitate both macromolecular uptake and secretion. The underlying endocytic and exocytic pathways are key mediators of a cell’s interaction with its environment, and may therefore show niche-specific adaptations. Our laboratory has taken a variety of approaches to identify key molecular determinants for membrane trafficking pathways in Tetrahymena. Studies of Rab GTPases, dynamins, and sortilin-family receptors substantiate the widespread conservation of some features but also uncover surprising roles for lineage-restricted innovation.

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The Plasmodium falciparum family of Rab GTPases

Cited by 81 publications

References 32 publications

Signalling in malaria parasites – The MALSIG consortium

Signalling in malaria parasites – The MALSIG consortium

Trafic protéique dans le globule rouge infecté parPlasmodium

Tetrahymena thermophila: A divergent perspective on membrane traffic

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