The Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya

Ochola, Lyticia A; Ng'wena, Gideon M; Noland, Gregory S.; Ondigo, Bartholomew N.; Ayodo, George; John, Chandy C.

doi:10.4103/0974-777x.122001

Cited by 2 publications

(1 citation statement)

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“…Earlier studies have shown that circulating levels of IFNγ and IL-10 were significantly higher in patients with severe malaria 314,315 . More recently, it was shown that Tr1 cells emerge as the dominant CD4 + T cell response in highly exposed children living in malaria endemic regions 47,48,232 .…”

Section: First Exposure To P Falciparum Induces Parasite-specific Trmentioning

confidence: 94%

Regulation of CD4+ T cell responses during parasitic infections

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observed a significant increase in TNF producing CD4 + T cells in the T cell specific Blimp1 deficient mice which was associated with extensive splenomegaly, a characteristic feature observed in patients with visceral leishmaniasis (VL). Importantly, Blimp1 transcripts were also found to be up-regulated in VL patients, indicating the clinical relevance of Blimp1 during infection. We sought to determine the mechanism by which Blimp1 was regulating pathology in the spleen. Firstly, we confirmed that the loss of MZM's in the T cell specific Blimp1 deficient mice was due to a lack of IL-10, where T cell-specific IL-10 deficient mice also displayed the same phenotype of MZM loss, and this process appeared to be TNF dependent. In support of IL-10 mediating protection against MZM loss, we were able to show that IL-10 signalling in T cells and myeloid-derived populations was a requirement for protection against TNF-mediated destruction. In summary, our data reveals a novel mechanism where Blimp1 induced IL-10 production by Tr1 cells limits pathology during infection. These findings have wider implications for other inflammatory diseases. I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the policy and procedures of The University of Queensland, the thesis be made available for research and study in accordance with the Copyright Act 1968 unless a period of embargo has been approved by the Dean of the Graduate School.I acknowledge that copyright of all material contained in my thesis resides with the copyright holder(s) of that material. Where appropriate I have obtained copyright permission from the copyright holder to reproduce material in this thesis.

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Section: First Exposure To P Falciparum Induces Parasite-specific Trmentioning

confidence: 94%

Regulation of CD4+ T cell responses during parasitic infections

de¹

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Functionally Relevant Proteins in Plasmodium Falciparum Host Cell Invasion

et al. 2017

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A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function.

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The Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya

Cited by 2 publications

References 32 publications

Regulation of CD4+ T cell responses during parasitic infections

Regulation of CD4+ T cell responses during parasitic infections

Functionally Relevant Proteins in Plasmodium Falciparum Host Cell Invasion

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