The plasma renin-angiotensin system in preeclampsia: Effects of magnesium sulfate

Sipes, Susan L.; Weiner, Carl P.; Gellhaus, Thomas M.; Goodspeed, J. D.

doi:10.1016/0020-7292(90)90207-2

Cited by 9 publications

(9 citation statements)

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“…Further, the reduced ECA activity in PIH could be related to the lack of therapeutic effect of ACE inhibitors in the treatment of PIH. 6 Our findings do not support those of others who reported that the level of serum ACE activity in PIH patients was higher 10,12,17 or not altered 13 when compared with those in normotensive pregnant women. This may reflect differences in gestational age, antihypertensive treatment and the method of determination.…”

Section: Discussioncontrasting

confidence: 99%

“…Several studies reported that the level of serum angiotensin-converting enzyme (ACE) activity in PIH patients was higher than that in normotensive pregnant women. [10][11][12] Another failed to find any difference in ACE activity between them. 13 Contrary to these results, we hypothesize that if plasma ANG II levels, plasma renin substrate and plasma renin concentration are all decreased in the third trimester in women with pregnancyinduced hypertension, it is likely that ANG II biosynthesis (ACE activity) also be altered in the same direction.…”

Section: Introductionmentioning

confidence: 99%

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Renin-angiotensin-aldosterone system in pregnancy-induced hypertension

Israel

Peceño

2000

J Hum Hypertens

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Angiotensin-converting enzyme (ACE) and aldosterone concentration were measured in the plasma of 32 pregnant women with normal blood pressure or with pregnancy-induced hypertension (PIH). Mean arterial pressure (MAP) in PIH women was significantly higher than in normotensive pregnant women. Plasma ACE activity and aldosterone concentration in 17 PIH patients was significantly lower than their normotensive counterparts

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renin-angiotensin-aldosterone system in pregnancy-induced hypertension

Israel

Peceño

2000

J Hum Hypertens

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“…Goldkrand and Fuentes [8] reported that the level of serum ACE activity in PIH patients was higher than that in normotensive pregnant women and chronic hyperten sive patients without PIH, which was supported by Sipes et al [9], However, others failed to find any difference in ACE activity between them [10], The results may be influenced by gestational age, antihypertensive treatment, diabetes mellitus, chronic hypertension and renal or he patic diseases as well as the method of determination. In this study, a highly sensitive hippuric acid colorimetric micromethod was used, and subjects were carefully select ed.…”

Section: Discussionsupporting

confidence: 48%

Serum Angiotensin-Converting Enzyme Activity in Pregnancy-Induced Hypertension

Jin¹,

Hu²,

Zhao³

1992

Gynecol Obstet Invest

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Angiotensin-converting enzyme (ACE) activity was measured in the serum of 33 pregnant women with normal blood pressure or pregnancy-induced hypertension (PIH) using sensitive hippuric acid colorimetric micromethods. Mean serum ACE activity in 17 PIH patients (73.25 ± 18.81 U/ml) was significantly higher than that in normotensive pregnant women (16 cases; 52.36 ± 9.91 U/ml; p < 0.01). Mean arterial blood pressure was correlated with the level of serum ACE activity in all pregnant women (y = 69.089 + 0.494x, r = 0.562, p < 0.01). In PIH patients, the gestosis index and the degree of edema also had a statistically significant correlation with the level of serum ACE activity (y = –0.560 + 0.056x, r = 0.549, p < 0.05; y = –1.760 + 0.043x, r = 0.629, p < 0.01). The amount of 24-hour urinary protein was independent of the level of serum ACE activity. It seems that a disturbance in the regulation of ACE activity may be one of the factors responsible for the development of PIH.

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“…It reduces postsynaptic membrane sensitivity and muscle membrane stimulation by decreasing the calcium transport in the presynaptic space and the release of acetylcholine. During general anesthesia, even in patients taking standard doses of magnesium sulphate, the effect of neuromuscular blocking agents can be potentialized, and their duration can be prolonged [15, 16]. Drugs with low biotransformation rates (like isoflurane), low renal clearance, short half-life, and low active metabolites (like atracurium) must be chosen for general anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Anesthesia and Intensive Care Management in a Pregnant Woman with PRES: A Case Report

Demirel

Özer²,

Bayar³

et al. 2012

Case Reports in Anesthesiology

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Posterior reversible encephalopathy syndrome (PRES) is a temporary condition that is diagnosed clinically, neurologically, and radiologically. Its symptoms vary, and nonspecific headaches, confusion, impairment of consciousness, nausea, vomiting, and visual impairment may occur. Acute hypertension often accompanies these symptoms. Patients can also suffer from convulsions, cortical visual impairment, and coma. Diagnosis can be difficult due to focal neurologic signs. Nevertheless, knowing the clinical risk factors can lead to the right diagnosis. It has been reported that this condition may also occur during organ transplantation, immunosuppressive treatment, and autoimmune diseases and chemotherapy, and also patients with eclampsia. In this paper, a 21-year-old, 31-week pregnant woman, who had been diagnosed with PRES and thanks to early diagnosis and treatment had fully recovered and discharged from the intensive care unit, is presented, and the relevant literature is discussed.

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The plasma renin-angiotensin system in preeclampsia: Effects of magnesium sulfate

Cited by 9 publications

References 0 publications

Renin-angiotensin-aldosterone system in pregnancy-induced hypertension

Renin-angiotensin-aldosterone system in pregnancy-induced hypertension

Serum Angiotensin-Converting Enzyme Activity in Pregnancy-Induced Hypertension

Anesthesia and Intensive Care Management in a Pregnant Woman with PRES: A Case Report

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