The Plasma Proteins in Liver Disease

Osserman, Elliott F.; Takatsuki, Kiyoshi

doi:10.1016/s0025-7125(16)33572-6

Cited by 20 publications

(2 citation statements)

References 80 publications

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“…An additional factor influencing drug distribution is represented by the binding with plasma proteins, because only the free form of the drug can spread within the extra-vascular space or within the cells where it exerts its effects. Of note, albumin binds acidic drugs, whereas acid alpha-glycoprotein and lipoprotein basic drugs, combined with several factors (i.e., liver and renal diseases, inflammation, cancers), may affect the concentration of plasma proteins available for drug binding [ 70 , 71 ].…”

Section: Changes Of Drug Distributionmentioning

confidence: 99%

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

et al. 2022

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Drugs and food interact mutually: drugs may affect the nutritional status of the body, acting on senses, appetite, resting energy expenditure, and food intake; conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. Therefore, the knowledge of these possible interactions is fundamental for the implementation of a nutritional treatment in the presence of a pharmacological therapy. This is the case of chronic kidney disease (CKD), for which the medication burden could be a problem, and nutritional therapy plays an important role in the patient’s treatment. The aim of this paper was to review the interactions that take place between drugs and foods that can potentially be used in renal patients, and the changes in nutritional status induced by drugs. A proper definition of the amount of food/nutrient intake, an adequate definition of the timing of meal consumption, and a proper adjustment of the drug dosing schedule may avoid these interactions, safeguarding the quality of life of the patients and guaranteeing the effectiveness of drug therapy. Hence, a close collaboration between the nephrologist, the renal dietitian, and the patient is crucial. Dietitians should consider that food may interact with drugs and that drugs may affect nutritional status, in order to provide the patient with proper dietary suggestions, and to allow the maximum effectiveness and safety of drug therapy, while preserving/correcting the nutritional status.

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Section: Changes Of Drug Distributionmentioning

confidence: 99%

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

et al. 2022

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“…High serum IgA values occur in patients with untreated coeliac disease, ulcerative colitis, and Crohn's disease (Asquith, Thompson, Cooke, 1969;Kraft, Ford, McCleery, and Kirsner, 1968) and high IgG and IgA levels have been recorded in hepatic cirrhosis and high IgM in biliary cirrhosis (McKelvey and Fahey, 1965;Osserman and Takatsuki, 1963;Feizi, 1968). Immunoglobulins in the serum have been studied in fibrocystic disease (Schwartz, 1966) and pancreatic juice immunoglobulins reported in 'calcifying pancreatitis' (Clemente, Ribeiro, Colomb, Figarella, and Sarles, 1971).…”

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confidence: 99%

Serum immunoglobulins in calcific pancreatitis

Bank¹,

Novis²,

Petersen³

et al. 1973

Gut

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SUMMARY Serum immunoglobulin concentrations were measured in 40 patients with calcific pancreatitis. A significant elevation of the mean serum IgA and IgG concentration when compared with a control group was found. The IgA was raised in 50 % and the IgG in 27.5 % when the individual results were assessed. The IgA did not appear to be of the secretory type.The possible significance of the raised IgA and IgG is discussed with reference to local pancreatic IgA production, autoimmune factors in chronic pancreatitis, and the ductal protein plugs in this disease.

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Serum Immunoglobulin Levels in Cystic Fibrosis

Schwartz¹

1966

Arch Pediatr Adolesc Med

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The Plasma Proteins in Liver Disease

Cited by 20 publications

References 80 publications

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Serum immunoglobulins in calcific pancreatitis

Serum Immunoglobulin Levels in Cystic Fibrosis

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