The Plasma Level of Matrix Metalloproteinase 9 may Predict the Natural History of Small Abdominal Aortic Aneurysms. A Preliminary Study

Lindholt, Jes Sanddal; Vammen, Sten; Fasting, H; Henneberg, E W; Heickendorff, Lene

doi:10.1053/ejvs.2000.1151

Cited by 145 publications

(117 citation statements)

References 30 publications

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“…Significant correlations with expansion were found in 2 studies (1 low and 1 medium bias risk; r =0.55 and r =0.42) with 61 follow‐up patients in total,10, 39 whereas 2 studies (1 low and 1 medium bias risk) could not reproduce such significant correlations in 66 follow‐up patients 18, 40. Pulinx et al, however, did reach significance when initial AAA diameter was included in their multivariate model 40…”

Section: Resultsmentioning

confidence: 88%

“…The quality appraisal attributed this study with medium bias risk. In 2 studies (1 medium and 1 high bias risk) no correlation was found in 91 follow‐up patients in total 9, 10. However, Satta et al did reach significance after 2 years of follow‐up 9…”

Section: Resultsmentioning

confidence: 95%

“…Flondell‐Sité et al, the largest study with the lowest risk of bias, found no correlation with AAA expansion in 163 follow‐up patients 32. In 2 smaller studies (medium bias risk), with 54 patients in total, significant correlations were described ( r =0.32 and r =0.33) 10, 33. Wilson et al (medium bias risk) demonstrated higher matrix metalloproteinase 9 levels in patients with a ruptured AAA than in patients preceding elective repair 34…”

Section: Resultsmentioning

confidence: 98%

“…In 3 studies, S‐elastin peptides (SEP) was investigated as a marker for expansion8, 10, 36 and 2 as a marker for rupture 37, 38. Lindholt et al performed 3 different studies, including 205 follow‐up patients in total, all demonstrating significant correlations with expansion ( r =0.51 [medium bias risk], r =0.33 [medium bias risk], and r =0.31 [low bias risk]).…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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BackgroundThe natural course of abdominal aortic aneurysms (AAA) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim was to identify potential prognostic markers for AAA growth and rupture.Methods and ResultsPotential circulating, biomechanical, and genetic markers were studied. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library in February 2017, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Study selection, data extraction, and methodological quality assessment were conducted by 2 independent researchers. Plausibility of markers was based on the amount of publications regarding the marker (more than 3), pooled sample size (more than 100), bias risk and statistical significance of the studies. Eighty‐two studies were included, which examined circulating (n=40), biomechanical (n=27), and genetic markers (n=7) and combinations of markers (n=8). Factors with an increased expansion risk included: AAA diameter (9 studies; n=1938; low bias risk), chlamydophila pneumonia (4 studies; n=311; medium bias risk), S‐elastin peptides (3 studies; n=205; medium bias risk), fluorodeoxyglucose uptake (3 studies; n=104; medium bias risk), and intraluminal thrombus size (5 studies; n=758; medium bias risk). Factors with an increased rupture risk rupture included: peak wall stress (9 studies; n=579; medium bias risk) and AAA diameter (8 studies; n=354; medium bias risk). No meta‐analysis was conducted because of clinical and methodological heterogeneity.ConclusionsWe identified 5 potential markers with a prognostic value for AAA growth and 2 for rupture. While interpreting these data, one must realize that conclusions are based on small sample sizes and clinical and methodological heterogeneity. Prospective and methodological consonant studies are strongly urged to further study these potential markers.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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“…1 Increased MMP-9 levels were detected in plasma of AAA patients and patients with acute coronary syndromes. 2,3 In addition, aneurysm and atherosclerotic tissues overexpress MMP-1, -2, -3, -7, -8, -9, -12, -13, -14, and -17 (Carrell et al 4 and references therein).…”

mentioning

confidence: 99%

Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth

et al. 2004

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Background-Epidemiological and histological evidence implicates proteinases of the matrix metalloproteinase (MMP) family in atherosclerosis and aneurysm formation. We previously indicated a role for urokinase-type plasminogen activator in atherosclerotic media destruction by proteolytic activation of MMPs. However, the role of specific MMPs, such as MMP-9 and MMP-12, in atherosclerosis remains undefined. Methods and Results-MMP-9 -or MMP-12-deficient mice were crossed in the atherosclerosis-prone apolipoprotein E-deficient background and fed a cholesterol-rich diet. Mice were killed at 15 or 25 weeks of diet to study intermediate and advanced lesions, respectively. Loss of MMP-9 reduced atherosclerotic burden throughout the aorta and impaired macrophage infiltration and collagen deposition, while MMP-12 deficiency did not affect lesion growth. MMP-9 or MMP-12 deficiency conferred significant protection against transmedial elastin degradation and ectasia in the atherosclerotic media. Conclusions-This study is the first to provide direct genetic evidence for a significant involvement of MMP-9, but not of MMP-12, in atherosclerotic plaque growth. In addition, deficiency of MMP-9 or MMP-12 protected apolipoprotein E-deficient mice against atherosclerotic media destruction and ectasia, mechanisms that implicate the involvement of

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Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

Smallwood

Allcock

Bockxmeer

et al. 2008

British Journal of Surgery

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The Plasma Level of Matrix Metalloproteinase 9 may Predict the Natural History of Small Abdominal Aortic Aneurysms. A Preliminary Study

Abstract: P-MMP9 and P-alpha 1 antitrypsin may predict the natural history of AAA.

Cited by 145 publications

References 30 publications

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth

Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

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