The Plasma Fats and the Iodine Absorption Capacity of the Fatty Acids in Hyperthyroidism

Nicholls, Elizabeth; Perlzweig, W. A.

doi:10.1172/jci100153

Cited by 18 publications

(5 citation statements)

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confidence: 55%

“…It must be stressed that from one patient to another the height of the basal metabolic rate was not proportional to the level of serum lipoids, but the close correlation between the different lipoids was obvious in each subject as an individual. Nicholls and Perlzweig (41) found similar changes in cholesterol and fatty acids of hyperthyroid patients. Boyd and Connell (8, 9) have pointed out that the neutral fat was diminished less than the total lipoid, total cholesterol, free cholesterol or phospholipoids.…”

Section: Discussionmentioning

confidence: 80%

“…Recent studies by Boyd indicate that total lipoids and phospholipids, as well as cholesterol, tend to be low in hyperthyroidism (7,8,9,10,11). Thus these recent studies on a large number of patients support the view that severe degrees of hyperthyroidism are usually associated with low levels of serum cholesterol (4,16,41,45,47).It is, however, probable that there are a considerable number of patients with severe hyperthyroidism who do not have low serum cholesterol or other fractions of the lipoids. A number of workers have reported that in patients with hyperthyroidism the blood or serum cholesterol may be within normal limits (1,3,15,28,30,44,52), or sometimes high (17,22,29,39,40,51).…”

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confidence: 70%

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Serum Lipoids and Proteins in Hyperthyroidism 1

Man

Gildea

Peters³

1940

J. Clin. Invest.

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It has been stated frequently that the level of serum cholesterol is as valuable an index of hyperthyroid activity as the basal metabolic rate. An examination of the literature, however, reveals controversial material to support this dictum. The present study was undertaken to determine how closely the level of serum cholesterol is related to the degree of thyroid activity and whether it is a useful criterion in the diagnosis of hyperthyroidism. It was thought of importance also to know if changes in the level of serum cholesterol after the administration of iodine might help in diagnosis in those questionable hyperthyroid patients whose basal metabolic rates do not respond to the ingestion of Lugol's solution. In addition to the cholesterol, basal metabolic rates, serum fatty acids, phosphatides and proteins of 65 patients with symptoms of hyperthyroidism have been determined at frequent intervals to learn: (1) whether there is an inverse relationship between basal metabolic rate and serum cholesterol, lipoid phosphorus, fatty acids and proteins; (2) if these serum constituents increase when the basal metabolic rate falls after the administration of iodine; and (3) if thyroidectomy always increases these components. The data on only 43 patients are presented in the tables because the other 22 patients were not completely studied. There were about 430 samples of blood sera in which the three lipoid fractions and proteins were determined during the 3 or more years that many of the patients have been followed.Hurxthal, Hunt and co-workers have studied the largest group of patients (23,24,25,26,38). Although they have employed a cholesterol colorimetric method described by Bloor in 1922, their results are reliable because they have devoted considerable attention to normal values. They have placed the low limit of normal for their method at 120 mgm. per cent, and the high limit at 300 1This work was aided in part by a grant from the Knight Fund, Yale University School of Medicine. mgm. per cent (26). In the study of patients with hyperthyroid disease these authors have found cholesterol values in a large majority of patients which were close to their low limit of normal. The rest of the values were distributed about equally on both sides of this figure (23). These authors have considered the possible effect of malnutrition on the serum cholesterol and have decided that it is of minor importance (23).They conclude that serum cholesterol is low in hyperthyroidism and that there is a relation between the severity of the disease and the level of cholesterol (23). Recent studies by Boyd indicate that total lipoids and phospholipids, as well as cholesterol, tend to be low in hyperthyroidism (7,8,9,10,11). Thus these recent studies on a large number of patients support the view that severe degrees of hyperthyroidism are usually associated with low levels of serum cholesterol (4,16,41,45,47).It is, however, probable that there are a considerable number of patients with severe hyperthyroidism who do not have low serum choles...

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supporting

confidence: 55%

Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 70%

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Serum Lipoids and Proteins in Hyperthyroidism 1

Man

Gildea

Peters³

1940

J. Clin. Invest.

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“…Two of the cases with a "positive" Van We have considered the possibility that the surface active substance which appears to be present may be an unsaturated compouna, possibly an unsaturated fatty acid. This aspect is further dealt with in the following paper (4). Under such circumstances the administration of iodine, even in the rather small amounts of Lugol 's solution which are effective therapeutically, might be sufficient to neutralize its effect.…”

Section: Discussionmentioning

confidence: 98%

The Surface Tension of the Blood Serum in Hyperthyroidism

Nicholls¹,

Harrop²

1928

J. Clin. Invest.

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The present communication is a report of an investigation of the surface tension of the blood serum in patients with severe thyroid intoxication. The general plan of the study has been as follows: Determinations of the surface tension were made upon samples of blood serum from untreated patients immediately upon admission to the hospital. Treatment with iodine (in the form of Lugol's solution) was then given in sufficient amount and over a sufficient period of time to allow an exhibition of its clinical effect, when the surface tension studies were repeated. Later the surface tension was again determined after surgical operation (double partial lobectomy of subtotal thyroidectomy) in order to observe any change resulting from the diminished activity of the thyroid gland due to its partial.removal. In some cases iodine was continued for a short time after operation.The direct reading tensiometer of Du Noiiy (1) was used for making the surface tension determinations, and all the precautions recommended by him were carefully followed. The watch glasses used were of uniform size (diameter 8 cm.) and the same amount of serum, approximately 2 cc., used each time. The glassware used was boiled for two hours in a concentrated solution of sulphuric acid to which had been added 15 cc. saturated solution of potassium bichromate per liter. The watch glasses were washed not longer than two or three days before using and were flamed a short time before use in order to insure uniform spreading of the serum. The greatest care was taken throughout to avoid touching with the hands any glassware, including the collecting apparatus, centrifuge tubes and watch glasses.The blood for the surface tension determinations was collected in 181

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“…4. Total fatty acids were increased in certain members of all groups except in patients with migraine and gallstones.…”

Section: Observationsmentioning

confidence: 91%