The Plasma Disappearance of Radioactive Cyanocobalamin: Effect of Prior Administration of Vitamin B<sub>12</sub> Analogues

Meyer, Leo M.; Schiffer, Lewis M.; White, David A.; Cronkite, Eugene P.

doi:10.1111/j.1365-2141.1965.tb06597.x

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The effect of normal serum was also examined (as described in paragraph 2). Normal values for plasma clearance activity following intravenous tracer doses of Co5i vitamin B,, are based on previous studies in this laboratory (Meyer et al 1965). clearance rate of radioactive Biz.…”

Section: Materials a N D M E T H O D Smentioning

confidence: 99%

Co⁵⁷ Vitamin B₁₂ Clearance Studies in Pernicious Anaemia

Meyer

Osofsky

Miller

1967

Scandinavian Journal of Haematology

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1) Clearance rate of intravenously administered radioactive vitamin B,, in untreated pernicious anaemia patients is slow in 50 per cent of cases studied.(2) Administration of labelled vitamin B,, bound to slow serum to 'normal clearing' pernicious anaemia subjects or to normal persons is followed by normal clearance rate.(3) Radioactive vitamin B,, bound to normal serum is cleared at a normal rate in pernicious anaemia patients with slow clearance rate. (4) Radioactive vitamin B,, bound to slow serum when mixed with normal serum in proportions of 1:l or 1 : O S is cleared at a normal rate in 'slow clearing' pernicious anaemia patients.( 5 ) These studies suggest the presence of a 'serum factor' in normal serum and some patients with pernicious anaemia in relapse which enhances clearance of vitamin B,, bound to 'slow serum'.

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Section: Materials a N D M E T H O D Smentioning

confidence: 99%

Co⁵⁷ Vitamin B₁₂ Clearance Studies in Pernicious Anaemia

Meyer

Osofsky

Miller

1967

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

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“…In a later study, Meyer et al (1965) compared the serum protein saturating or blocking effect of various analogs of cyanocobalamin. It was found that hydroxocobalamin was the most potent analog in promoting rapid plasma disappearance of injected radioactive cyanocobalamin; the aquanalide analog had an intermediate effect, while the others tested had no effect.…”

Section: Relationship Of Structure and Protein Bindingmentioning

confidence: 99%