The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus

Linzner, Nico; Fritsch, Verena Nadin; Busche, Tobias; Tung, Quach Ngoc; Loi, Vu Van; Bernhardt, Jörg; Kalinowski, Jörn; Antelmann, Haike

doi:10.1016/j.freeradbiomed.2020.07.025

Cited by 28 publications

(25 citation statements)

References 71 publications

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“…Nevertheless, multiplication in recent years of studies by -omics approaches opens the possibility to identify new mechanisms of action or to identify several mechanisms of action acting simultaneously (which is generally the case at least for plant extracts and even for some pure plant phenolics). Transcriptomics ( Alvarado-Martinez et al, 2020 ; Linzner et al, 2020 ; Reverón et al, 2020 ), proteomics ( Ozdemir and Soyer, 2020 ) and metabolomics ( Wu et al, 2020 ) approaches recently contributed to the identification of targets of antimicrobial action of some plant phenolics or phenolic-rich plant extracts. Transcriptomic ( Reverón et al, 2020 ) and metabolomic ( Wu et al, 2020 ) analyses allow to identify which metabolic pathways are affected by plant phenolics.…”

Section: Diversity Of Antimicrobial Mechanism Of Action Of Plant Phenolicsmentioning

confidence: 99%

“…However, despite their structural diversity, no clear general rule regarding the antimicrobial activity spectrum or the mechanisms of action of a class of plant phenolics could be established to date. Nevertheless, the interested reader can refer to several reviews or articles focused on the antimicrobial activity of each phenolic class: phenolic acids ( Wen et al, 2003 ; Cueva et al, 2010 ; Borges et al, 2013 ; Pernin et al, 2019 ), flavonoids ( Cushnie and Lamb, 2005 ), tannins ( Scalbert, 1991 ), stilbenoids ( Plumed-Ferrer et al, 2013 ), quinones ( Linzner et al, 2020 ), and coumarins ( Duggirala et al, 2014 ). Several authors also presented reviews on phenolic-rich plant extracts or plant phenolics acting on one ( L. monocytogenes , Zamuz et al, 2021 ) or several ( Ullah et al, 2020 ) foodborne pathogenic microorganisms.…”

Section: Diversity Of Antimicrobial Mechanism Of Action Of Plant Phenolicsmentioning

confidence: 99%

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Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Oulahal

Degraeve

2022

Front. Microbiol.

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In recent years, the search for natural plant-based antimicrobial compounds as alternatives to some synthetic food preservatives or biocides has been stimulated by sanitary, environmental, regulatory, and marketing concerns. In this context, besides their established antioxidant activity, the antimicrobial activity of many plant phenolics deserved increased attention. Indeed, industries processing agricultural plants generate considerable quantities of phenolic-rich products and by-products, which could be valuable natural sources of natural antimicrobial molecules. Plant extracts containing volatile (e.g., essential oils) and non-volatile antimicrobial molecules can be distinguished. Plant essential oils are outside the scope of this review. This review will thus provide an overview of current knowledge regarding the promises and the limits of phenolic-rich plant extracts for food preservation and biofilm control on food-contacting surfaces. After a presentation of the major groups of antimicrobial plant phenolics, of their antimicrobial activity spectrum, and of the diversity of their mechanisms of action, their most promising sources will be reviewed. Since antimicrobial activity reduction often observed when comparing in vitro and in situ activities of plant phenolics has often been reported as a limit for their application, the effects of the composition and the microstructure of the matrices in which unwanted microorganisms are present (e.g., food and/or microbial biofilms) on their activity will be discussed. Then, the different strategies of delivery of antimicrobial phenolics to promote their activity in such matrices, such as their encapsulation or their association with edible coatings or food packaging materials are presented. The possibilities offered by encapsulation or association with polymers of packaging materials or coatings to increase the stability and ease of use of plant phenolics before their application, as well as to get systems for their controlled release are presented and discussed. Finally, the necessity to consider phenolic-rich antimicrobial plant extracts in combination with other factors consistently with hurdle technology principles will be discussed. For instance, several authors recently suggested that natural phenolic-rich extracts could not only extend the shelf-life of foods by controlling bacterial contamination, but could also coexist with probiotic lactic acid bacteria in food systems to provide enhanced health benefits to human.

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Section: Diversity Of Antimicrobial Mechanism Of Action Of Plant Phenolicsmentioning

confidence: 99%

Section: Diversity Of Antimicrobial Mechanism Of Action Of Plant Phenolicsmentioning

confidence: 99%

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Oulahal

Degraeve

2022

Front. Microbiol.

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“…Um total de 14 atividades potenciais diferentes já foram descritas na literatura sobre esse gênero e a maioria dos artigos atribui esses potenciais a três principais compostos: Lapachol, β-Lapachona e α-Lapachona. Esses compostos são derivados das naftoquinonas que são metabólitos secundários das plantas e dividem-se em 1,2-e 1,4-naftoquinonas e, em função da presença de anel heterocíclico oxigenado, ainda podem ser classificadas como prenilnaftoquinonas, furanonaftoquinonas, difuronaftoquinonas e piranonaftoquinonas, apresentando diversidade em relação a sua estrutura dentro do gênero Tabebuia (Linzner et al, 2020).…”

Section: A) B)unclassified

Prospecção científica e tecnológica da Tabebuia reseoalba (Ipê-branco)

Pereyra

Santos

Rocha

et al. 2021

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A Tabebuia roseoalba, conhecida popularmente como Ipê-branco, uma planta nativa do cerrado e pantanal brasileiro. Por possuir inúmeras substâncias de interesse terapêutico, há perspectivas de servirem como alternativa no controle de infecções. Com o intuito de verificar a importância dos extratos de Tabebuia roseoalba no cunho científico, foram feitas pesquisas a fim de se confirmar a relevância que o presente trabalho apresenta como inovação tecnológica. Os resultados encontrados nas bases de dados Science Direct e Pubmed, assim como patentes encontradas nos bancos de patentes World Intelectual Property Organization (WIPO) e Instituto Nacional da Propriedade Industrial (INPI), foram métodos eficazes para a construção dessa Prospecção. A partir das palavras-chaves antimicrobianos, resistência bacteriana, Bignoniaceae, Tabebuia e Tabebuia roseoalba, na língua inglesa e portuguesa, quando necessário, na base de patentes WIPO revelou 135.638 patentes para antimicrobial, 78.108 para bacterial resistence, 69 para Bignoniaceae, 167 para Tabebuia e 0 para Tabebuia roseoalba. No INPI foram obtidas 1.377 para antimicrobiano, 2.510 para resistência bacteriana, 38 para Bignoniaceae, 31 para Tabebuia e 3 para Tabebuia roseoalba. A partir dos resultados obtidos mediante as buscas de patentes acerca da utilização de potenciais antimicrobiano de Tabebuia roseoalba para o combate de agentes patogênicos, pode-se concluir que o estudo forneceu dados de prospecção científico-tecnológico, visto que auxiliou como uma boa ferramenta para a realização da presente pesquisa pode-se ressaltar a importância da análise prospecção tecnológica, como um meio benéfico no qual pode promover a capacidade de organizar a pesquisa inovadora com base nos interesses e necessidades da sociedade.

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“…The natural naphthoquinone lapachol induced oxidative stress (ROS formation) against Staphylococcus aureus, a human pathogen rapidly acquiring multidrug resistance. The level of oxidation by lapachol was determined using S. aureus expressing the biosensor plasmids (Linzner et al, 2020), where the biosensor fluorescence emission was measured at 510 nm; a similar biosensor was further applied against a mycoredoxinnull mutant of Rhodococcus equi (mammalian pathogen) to screen ROS-generating antibiotics exerting drug synergism (Mourenza et al, 2020). Meanwhile, the use of photosensitizers was investigated in photodynamic therapy against the yeast pathogen Candida albicans, where the production of ROS was determined using an electron paramagnetic resonance spectrometer (Kanpittaya et al, 2021).…”

Section: Redox-active Molecules As Antimicrobials: Mechanisms and Resistancementioning

confidence: 99%

Editorial: Redox-Active Molecules as Antimicrobials: Mechanisms and Resistance

et al. 2021

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The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus

Cited by 28 publications

References 71 publications

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides?

Prospecção científica e tecnológica da Tabebuia reseoalba (Ipê-branco)

Editorial: Redox-Active Molecules as Antimicrobials: Mechanisms and Resistance

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