The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

Yang, Mingkang; Zhu, Xiao‐Jie; Chen, Chumin; Guo, Xu; Xu, Shuxuan; Xu, Ya‐Rou; Du, Shenxiu; Xiao, Shi; Mueller‐Roeber, Bernd; Huang, Wei; Chen, Liang

doi:10.1111/jipb.13343

Cited by 7 publications

(2 citation statements)

References 66 publications

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“…Temperature changes also affect the expression of circadian clock components such as LUX . Despite these findings, the mechanism by which plant circadian clocks respond to cold stress is still not fully understood (Yang et al, 2022). But the mechanism underlying the ABA‐induced expression of circadian clock genes has not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Appropriate induction of TOC1 ensures optimal MYB44 expression in ABA signaling and stress response in Arabidopsis

Du,

Wang,

et al. 2024

Plant Cell & Environment

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Plants possess the remarkable ability to integrate the circadian clock with various signalling pathways, enabling them to quickly detect and react to both external and internal stress signals. However, the interplay between the circadian clock and biological processes in orchestrating responses to environmental stresses remains poorly understood. TOC1, a core component of the plant circadian clock, plays a vital role in maintaining circadian rhythmicity and participating in plant defences. Here, our study reveals a direct interaction between TOC1 and the promoter region of MYB44, a key gene involved in plant defence. TOC1 rhythmically represses MYB44 expression, thereby ensuring elevated MYB44 expression at dawn to help the plant in coping with lowest temperatures during diurnal cycles. Additionally, both TOC1 and MYB44 can be induced by cold stress in an Abscisic acid (ABA)‐dependent and independent manner. TOC1 demonstrates a rapid induction in response to lower temperatures compared to ABA treatment, suggesting timely flexible regulation of TOC1‐MYB44 regulatory module by the circadian clock in ensuring a proper response to diverse stresses and maintaining a balance between normal physiological processes and energy‐consuming stress responses. Our study elucidates the role of TOC1 in effectively modulating expression of MYB44, providing insights into the regulatory network connecting the circadian clock, ABA signalling, and stress‐responsive genes.

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Section: Discussionmentioning

confidence: 99%

Appropriate induction of TOC1 ensures optimal MYB44 expression in ABA signaling and stress response in Arabidopsis

Du,

Wang,

et al. 2024

Plant Cell & Environment

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“…ACBP3 can be induced by pathogens and is subjected to circadian regulation (Zheng et al, 2012 ). It appears plausible, yet remains to be confirmed, that ACBP3 is secreted through an autophagy‐dependent process, which is known to be subjected to marked circadian fluctuations in plants (Chen et al, 2022 ; Yang, Zhu, et al, 2022 ).…”

Section: Autophagy‐dependent Secretion Of Acbp / ...mentioning

confidence: 99%

Acyl coenzyme A binding protein (ACBP): An aging‐ and disease‐relevant “autophagy checkpoint”

et al. 2023

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Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI), is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic radiation. In several eukaryotic phyla, ACBP/DBI transcends its intracellular function in fatty acid metabolism because it can be released into the extracellular space. This ACBP/DBI secretion usually occurs in response to nutrient scarcity through an autophagy‐dependent pathway. ACBP/DBI and its peptide fragments then act on a range of distinct receptors that diverge among phyla, namely metabotropic G protein‐coupled receptor in yeast (and likely in the mammalian central nervous system), a histidine receptor kinase in slime molds, and ionotropic gamma‐aminobutyric acid (GABA)A receptors in mammals. Genetic or antibody‐mediated inhibition of ACBP/DBI orthologs interferes with nutrient stress‐induced adaptations such as sporulation or increased food intake in multiple species, as it enhances lifespan or healthspan in yeast, plant leaves, nematodes, and multiple mouse models. These lifespan and healthspan‐extending effects of ACBP/DBI suppression are coupled to the induction of autophagy. Altogether, it appears that neutralization of extracellular ACBP/DBI results in “autophagy checkpoint inhibition” to unleash the anti‐aging potential of autophagy. Of note, in humans, ACBP/DBI levels increase in various tissues, as well as in the plasma, in the context of aging, obesity, uncontrolled infection or cardiovascular, inflammatory, neurodegenerative, and malignant diseases.

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The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

Cited by 7 publications

References 66 publications

Appropriate induction of TOC1 ensures optimal MYB44 expression in ABA signaling and stress response in Arabidopsis

Appropriate induction of TOC1 ensures optimal MYB44 expression in ABA signaling and stress response in Arabidopsis

Acyl coenzyme A binding protein (ACBP): An aging‐ and disease‐relevant “autophagy checkpoint”

OsTOC1 plays dual roles in the regulation of plant circadian clock by functioning as a direct transcription activator or repressor

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